2-Butyl-3-(p-tolyl)quinuclidine

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2-Butyl-3-(p-tolyl)quinuclidine
Systematic (IUPAC) name
(7R,8S)-7-Butyl-8-(4-methylphenyl)-1-azabicyclo[2.2.2]octane
Identifiers
CAS number	?
ATC code	?
PubChem	9903250
Chemical data
Formula	C18H27N
Mol. mass	257.414 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Legal
Routes	?

2-Butyl-3-(p-tolyl)quinuclidine (BTQ) is a stimulant drug which acts as a dopamine reuptake inhibitor.^[1] It is one of a number of substituted quinuclidine derivatives developed as potential medications for the treatment of cocaine abuse,^[2][3] and produces similar effects to cocaine in animal studies, although milder and longer lasting.

[edit] References

1. ^ Sakamuri S, Enyedy IJ, Kozokowski AP, Wang S. Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors. Tetrahedron Letters. 2000; 41:9949-9952.
2. ^ Sakamuri S, Enyedy IJ, Zaman WA, Tella SR, Kozikowski AP, Flippen-Anderson JL, Farkas T, Johnson KM, Wang S. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic and Medicinal Chemistry. 2003 Mar 20;11(6):1123-36. PMID 12614900
3. ^ Enyedy IJ, Sakamuri S, Zaman WA, Johnson KM, Wang S. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic and Medicinal Chemistry Letters. 2003 Feb 10;13(3):513-7. PMID 12565962

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