3,4-Dimethylamphetamine

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3,4-Dimethylamphetamine
Systematic (IUPAC) name
1-(3,4-dimethylphenyl)propan-2-amine
Identifiers
CAS number	14543-76-1
ATC code	?
PubChem	26727
Chemical data
Formula	C11H17N
Mol. mass	163.259 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

3,4-Dimethylamphetamine (Xylopropamine, α,3,4-trimethylphenethylamine) is a stimulant drug derived from amphetamine which was invented in the 1950s.

Xylopropamine was developed as an appetite suppressant in the 1950s and briefly sold as the sulfate salt, but it was not widely marketed. Other related amphetamine derivatives such as 2,4-dimethylamphetamine were also investigated for the same purpose, however these drugs had negative side effects such as high blood pressure and were not very successful, mainly due to the introduction of alternative drugs such as phentermine which had similar efficacy but less side effects.

Xylopropamine was also reported as having analgesic^[1] and anti-inflammatory^[2] effects but its side effects profile meant that it was never further developed for these applications.

[edit] References

1. ^ HARRIS SC, WORLEY RC. Analgesic properties of xylopropamine. Proceedings of the Society for Experimental Biology and Medicine. 1957 Jun;95(2):212-5.
2. ^ RANDALL LO, SELITTO JJ, VALDES J. Anti-inflammatory effects of xylopropamine. Archives Internationales de Pharmacodynamie et de Therapie. 1957 Dec 1;113(1-2):233-49.

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v • d • e Amphetamines (N06BA) Amphetamine/Dextroamphetamine, Dextromethamphetamine, Levomethamphetamine, 4-FMP, 4-MTA, Benzphetamine, Ethylamphetamine, Propylamphetamine, MDMA, MDA, MDEA, N-methyl-β-hydroxyamphetamine, Parahydroxyamphetamine, Paramethoxyamphetamine, Paramethoxymethamphetamine, Paramethoxyethylamphetamine, Xylopropamine