(-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate

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(-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate
Systematic (IUPAC) name
methyl (3S,4S)-1-methyl-4-naphthalen-2-ylpiperidine-3-carboxylate
Identifiers
CAS number  ?
ATC code  ?
PubChem 10684403
Chemical data
Formula C18H21NO2 
Mol. mass 283.364
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

(-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate is a piperidine based stimulant drug which is synthesised from arecoline. It is similar to nocaine in chemical structure, and has and a half times more activity than cocaine as a dopamine reuptake inhibitor. However it is also a potent serotonin reuptake inhibitor, with similar affinity to fluoxetine.[1] It is a structural isomer of another potent dopamine reuptake inhibitor, HDMP-28.

[edit] References

  1. ^ Further SAR Studies of Piperidine-Based Analogues of Cocaine. 2. Potent Dopamine and Serotonin Reuptake Inhibitors. Retrieved on 2008-01-11.

[edit] See also


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Piperidines

2-Benzylpiperidine • Desoxypipradrol • Ethylphenidate • HDMP-28 • (-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate • Methylphenidate (Dexmethylphenidate) • Nocaine • Phacetoperane • Pipradrol
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