Nordazepam

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Nordazepam
Systematic (IUPAC) name
9-chloro-6-phenyl-
2,5-diazabicyclo[5.4.0]undeca-
5,8,10,12-tetraen-3-one
Identifiers
CAS number 1088-11-5
ATC code N05BA16
PubChem 2997
DrugBank none
Chemical data
Formula C15H11ClN2O 
Mol. mass 270.71
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 50-120 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?
Legal status

Schedule IV(US)
Routes Oral

Nordazepam (marketed under brand names Stilny, Madar, Vegesan, and Calmday), also known as nordiazepam and desmethyldiazepam, is a 1,4-benzodiazepine derivative. Like other benzodiazepine derivatives, it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties. However, it is used primarily in the treatment of anxiety. It is an active metabolite of diazepam, chlordiazepoxide, clorazepate, prazepam, and medazepam.[1]

Contents

[edit] Side effects

Common side effects of nordazepam include somnolence, which is more common in elderly patients and/or people on high dose regimens. Hypotonia, which is much less common, is also associated with high doses and/or old age.

[edit] Interactions

Benzodiazepines including N-desmethyldiazepam (nordazepam) may inhibit the glucuronidation of morphine leading to increased levels of and prolongation of the effects of morphine.[2]

[edit] Abuse

Nordazepam and other sedative hypnotic drugs are detected frequently in cases of people suspected of driving under the influence of drugs. Other benzodiazepines and zolpidem and zopiclone are also found in high numbers of suspected drugged drivers. Many drivers have blood levels far exceeding the therapeutic dose range suggesting a high degree of abuse potential for benzodiazepines and zolpidem and zopiclone.[3]

[edit] External links

[edit] References

  1. ^ Biam. NORDAZEPAM (French). Retrieved on 18 October 2005.
  2. ^ Pacifici GM; Gustafsson LL, Säwe J, Rane A. (Apr 1986). "Metabolic interaction between morphine and various benzodiazepines.". Acta Pharmacol Toxicol (Copenh). 58 (4): 249–52. PMID 2872767. 
  3. ^ Jones AW; Holmgren A, Kugelberg FC. (Apr 2007). "Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results.". Ther Drug Monit. 29 (2): 248–60. doi:10.1097/FTD.0b013e31803d3c04. PMID 17417081. 
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