Clotiazepam



Clotiazepam
Systematic (IUPAC) name
2-(2-chlorophenyl)-9-ethyl-6-methyl- 8-thia-3,6-diazabicyclo[5.3.0]deca-2,9,11-trien-5-one
Identifiers
CAS number	33671-46-4
ATC code	N05BA21
PubChem	2811
DrugBank	?
Chemical data
Formula	C₁₆H₁₅Cl N₂O S
Mol. mass	318.8 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	?
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status	Schedule IV(US)
Routes	Oral

Clotiazepam (marketed under brand name Trecalmo) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Stage 2 NREM sleep is significantly increased by clotiazepam.^[1]

Clotiazepam is not approved for sale in the United States or Canada.

[edit] References

^ Nakazawa Y; Kotorii M, Oshima M, Horikawa S, Tachibana H. (31). "Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives.". Psychopharmacologia. 44 (2): 165–71. doi:10.1007/BF00421005. PMID 709.

v • d • e Benzodiazepines (N05BA, N05CD)

1,4-Benzodiazepines	Bromazepam • Camazepam • Chlordiazepoxide • Cinolazepam • Clonazepam • Clorazepate • Cyprazepam • Delorazepam • Diazepam • Doxefazepam • Elfazepam • Ethyl loflazepate • Fletazepam • Fludiazepam • Fosazepam • Flunitrazepam • Flurazepam • Flutoprazepam • Gidazepam • Halazepam • Iclazepam • Lorazepam • Lormetazepam • Meclonazepam • Medazepam • Menitrazepam • Metaclazepam • Nimetazepam • Nitrazepam • Nordazepam • Oxazepam • Phenazepam • Pinazepam • Pivoxazepam • Prazepam • Premazepam • Quazepam • QH-II-66 • Reclazepam • Sulazepam • Temazepam • Tetrazepam • Uldazepam

Triazolobenzodiazepines	Adinazolam • Alprazolam • Estazolam • Triazolam • Zapizolam

Imidazobenzodiazepines	Bretazenil • Flumazenil • Imidazenil • Loprazolam • Midazolam • Ro15-4513 • Ro48-6791

Oxazolobenzodiazepines	Cloxazolam • Flutazolam • Haloxazolam • Mexazolam • Oxazolam

Thienobenzodiazepines	Brotizolam • Clotiazepam • Etizolam

1,5-Benzodiazepines	Arfendazam • Clobazam • Lofendazam • Razobazam • Triflubazam

2,3-Benzodiazepines	Girisopam • GYKI-52895 • Nerisopam • Tofisopam

Benzodiazepine Prodrugs	Avizafone • Rilmazafone

Others	Bentazepam • Ketazolam • Olanzepine • Tifluadom • Zolazepam

v • d • e Psycholeptics: anxiolytics (tranquilisers) (N05B)

Benzodiazepine	Adinazolam - Alprazolam - Bretazenil - Bromazepam - Camazepam - Chlordiazepoxide - Clobazam - Clorazepate - Clonazepam - Clotiazepam - Cloxazolam - Diazepam - Ethyl loflazepate - Etizolam - Fludiazepam - Halazepam - Imidazenil - Ketazolam - Lorazepam - Medazepam - Nordazepam - Oxazepam - Pinazepam - Prazepam - Tofisopam

Nonbenzodiazepine	Adipiplon - Alpidem - CGS-9896 - CGS-20625 - Etifoxine - L-838,417 - Ocinaplon - Pagoclone - Panadiplon - Pipequaline - RWJ-51204 - Y-23684

Diphenylmethane	Hydroxyzine - Captodiame

Carbamates	Emylcamate - Carisoprodol - Mebutamate - Meprobamate - Phenprobamate - Tybamate

β-Carbolines	Abecarnil - Gedocarnil - SL-651,498

Dibenzo-bicyclo-octadiene	Benzoctamine

Azaspirodecanedione (serotonin agonist)	Buspirone - Gepirone - Tandospirone

Other	Eglumegad - Etazolate - Flesinoxan - Mephenoxalone - Saredutant