Etizolam
From Wikipedia, the free encyclopedia
 |
|
 |
|
|
Etizolam
|
|
| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | |
| ATC code | N05 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C17H15ClN4S |
| Mol. mass | 342.8 |
| Pharmacokinetic data | |
| Bioavailability | 93% |
| Metabolism | Hepatic |
| Half life | about 6 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
Etizolam (marketed under the brand name Sedekopan or Depas) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
Etizolam is not approved for sale in the United States or Canada.
Contents |
[edit] Indications
- Short-term treatment of insomnia
- Short-term treatment of anxiety or panic attacks, if a benzodiazepine is required
[edit] Dosage
- For anxiety: 0,25-0,50 mg two or three times per day (maximum 2 mg per day)
- For insomnia: 1 or 2 mg before bedtime
[edit] Pharmacology
According to the Italian P.I. sheet (please correct my poor English please):
Etizolam belongs to a new class of diazepines, thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time and a reduction in the number of awakenings. During tests there were not substantial changes in deep sleep. There is a reduction of REM sleep, but REM rebound at the end of treatment was not seen. In EEG tests of healthy volunteers Etizolam showed some characteristics of tricyclic antidepressants. Etizolam is free of significant effects on the cardiovascular and respiratory systems.
In men, peak time is at 3.2 hours, and half-life is about 6.2 hours. So it can be classified as a short-medium action bendodiazepine.
[edit] External links
|
||||||||||||||||||||||||||
