Mothers against decapentaplegic homolog 7

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SMAD family member 7
Solution Structure Of Smurf2 Ww3 Domain-Smad7 Py Peptide Complex
Identifiers
Symbol(s) SMAD7; MADH7; FLJ16482; MADH8
External IDs OMIM: 602932 MGI: 1100518 HomoloGene: 4314
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4092 17131
Ensembl ENSG00000101665 n/a
Uniprot O15105 n/a
Refseq NM_005904 (mRNA)
NP_005895 (protein)		 XM_986975 (mRNA)
XP_992069 (protein)
Location Chr 18: 44.7 - 44.73 Mb n/a
Pubmed search [1] [2]

SMAD7 or Mothers against decapentaplegic homolog 7 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of ligands. Like many other TGFβ family members SMAD7 is involved in cell signalling. It is a TGFβ type 1 receptor antagonist. It blocks TGFβ1 and activin associating with the receptor and blocking access to SMAD2. It is an inhibitory SMAD (I-SMAD) and is enhanced by SMURF2.

[edit] Further reading

  • Massagué J (1998). "TGF-beta signal transduction.". Annu. Rev. Biochem. 67: 753–91. doi:10.1146/annurev.biochem.67.1.753. PMID 9759503. 
  • Verschueren K, Huylebroeck D (2000). "Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.". Cytokine Growth Factor Rev. 10 (3-4): 187–99. PMID 10647776. 
  • Wrana JL, Attisano L (2000). "The Smad pathway.". Cytokine Growth Factor Rev. 11 (1-2): 5–13. PMID 10708948. 
  • Miyazono K (2000). "TGF-beta signaling by Smad proteins.". Cytokine Growth Factor Rev. 11 (1-2): 15–22. PMID 10708949. 
  • Hayashi H, Abdollah S, Qiu Y, et al. (1997). "The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.". Cell 89 (7): 1165–73. PMID 9215638. 
  • Topper JN, Cai J, Qiu Y, et al. (1997). "Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.". Proc. Natl. Acad. Sci. U.S.A. 94 (17): 9314–9. PMID 9256479. 
  • Nakao A, Afrakhte M, Morén A, et al. (1997). "Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.". Nature 389 (6651): 631–5. doi:10.1038/39369. PMID 9335507. 
  • Röijer E, Morén A, ten Dijke P, Stenman G (1998). "Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 81 (3-4): 189–90. PMID 9730599. 
  • Itóh S, Landström M, Hermansson A, et al. (1998). "Transforming growth factor beta1 induces nuclear export of inhibitory Smad7.". J. Biol. Chem. 273 (44): 29195–201. PMID 9786930. 
  • Datta PK, Moses HL (2000). "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.". Mol. Cell. Biol. 20 (9): 3157–67. PMID 10757800. 
  • Denissova NG, Pouponnot C, Long J, et al. (2000). "Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter.". Proc. Natl. Acad. Sci. U.S.A. 97 (12): 6397–402. doi:10.1073/pnas.090099297. PMID 10823886. 
  • Stopa M, Anhuf D, Terstegen L, et al. (2000). "Participation of Smad2, Smad3, and Smad4 in transforming growth factor beta (TGF-beta)-induced activation of Smad7. THE TGF-beta response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation.". J. Biol. Chem. 275 (38): 29308–17. doi:10.1074/jbc.M003282200. PMID 10887185. 
  • Kavsak P, Rasmussen RK, Causing CG, et al. (2001). "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.". Mol. Cell 6 (6): 1365–75. PMID 11163210. 
  • Ebisawa T, Fukuchi M, Murakami G, et al. (2001). "Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.". J. Biol. Chem. 276 (16): 12477–80. doi:10.1074/jbc.C100008200. PMID 11278251. 
  • Itoh F, Asao H, Sugamura K, et al. (2001). "Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.". EMBO J. 20 (15): 4132–42. doi:10.1093/emboj/20.15.4132. PMID 11483516. 
  • Yanagisawa M, Nakashima K, Takeda K, et al. (2002). "Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7.". Genes Cells 6 (12): 1091–9. PMID 11737269. 


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Cell signaling: TGF beta signaling pathway
TGF beta superfamily of ligands
TGF beta receptors
Transducers/SMAD
Ligand Inhibitors
Coreceptors
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