Mothers against decapentaplegic homolog 5

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SMAD, Mothers against decapentaplegic homolog 5
Other names:	SMAD 5, Mothers against DPP homolog 5, Smad5, hSmad5, JV5-1
Genetic data
Gene code:	HUGO code:SMAD5
Protein Structure/Function
Protein type:	R-SMAD
Functions:	signal transduction, transcription
Domains:	MH1, MH2
Other
Taxa expressing:	homo sapiens; homolog: many metazoan phyla
Cell types:	ubiquitous
Subcellular localization:	Primary:nucleus, Alternative:cytoplasm
Covalent modifications:	phosphorylation

SMAD5 or Mothers against decapentaplegic homolog 5 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.

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Identifiers
Symbol	SMAD5
Alt. Symbols	MADH5, Dwfc, JV5-1
Entrez	4090
HUGO	6771
OMIM	603110
RefSeq	NM_005903
UniProt	Q99717
Other data
Locus	Chr. 5 q31

v • d • e Cell signaling: TGF beta signaling pathway TGF beta superfamily of ligands TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) TGF beta receptors TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan Transducers/SMAD R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 Ligand Inhibitors Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 Coreceptors BAMBI - Cripto Other SARA