Chordin

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Chordin
Genetic data
Gene code:	HUGO code:CHRD
Protein Structure/Function
Protein type:	chordin family member
Functions:	dorsalizing factor
Domains:	4 CHRD domains, 4 VWFC domains
Other
Taxa expressing:	many metazoan phyla
Cell types:	many
Subcellular localization:	extracellular

Chordin is a polypeptide that dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as Bone morphogenetic proteins. It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.

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Identifiers
Symbol	CHRD
Entrez	8646
HUGO	1949
OMIM	603475
RefSeq	NM_003741
UniProt	Q9H2X0
Other data
Locus	Chr. 3 q27

v • d • e Cell signaling: TGF beta signaling pathway TGF beta superfamily of ligands TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) TGF beta receptors TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan Transducers/SMAD R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 Ligand Inhibitors Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 Coreceptors BAMBI - Cripto Other SARA