Acetoacetyl-CoA

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Acetoacetyl-CoA
Identifiers
CAS number	[1420-36-6]
PubChem	74
MeSH	acetoacetyl+CoA
Properties
Molecular formula	C25H40N7O18P3S
Molar mass	851.609 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Acetoacetyl CoA is precursor of HMG-CoA in the Mevalonate pathway.

It is created from acetyl-CoA by thiolase, and it is acted upon by HMG-CoA synthase to form HMG-CoA. (During the metabolism of leucine, this last reaction is reversed.)

[edit] See also

• Beta-hydroxybutyryl-CoA dehydrogenase

v • d • e Cholesterol metabolic intermediates to HMG-CoA Acetyl-CoA - Acetoacetyl-CoA - HMG-CoA to Dimethylallyl pyrophosphate Mevalonic acid - Phosphomevalonic acid - 5-Diphosphomevalonic acid - Isopentenyl pyrophosphate - Dimethylallyl pyrophosphate Geranyl- Geranyl pyrophosphate - Geranylgeranyl pyrophosphate To Cholesterol Farnesyl pyrophosphate - Squalene - 2,3-Oxidosqualene - Lanosterol see also enzymes

v • d • e Amino acid metabolism metabolic intermediates K→acetyl-CoA lysine→ Saccharopine - Allysine - Alpha-aminoadipate - Alpha-ketoadipic acid - Glutaryl-CoA - Glutaconyl-CoA - Crotonyl-CoA - Beta-hydroxybutyryl-CoA leucine→ Alpha-ketoisocaproic acid - Isovaleryl-CoA - 3-Methylcrotonyl-CoA - 3-Methylglutaconyl-CoA - HMG-CoA tryptophan→alanine→ N'-Formylkynurenine - Kynurenine - Anthranilic acid - 3-hydroxykynurenine - 3-Hydroxyanthranilic acid - 2-Amino-3-carboxymuconic semialdehyde - 2-Aminomuconic semialdehyde - 2-Aminomuconic acid - Glutaryl-CoA G→glutamate histidine→ Urocanic acid - Imidazol-4-one-5-propionic acid - Formiminoglutamic acid - Glutamate-1-semialdehyde proline→ 1-Pyrroline-5-carboxylic acid arginine→ Ornithine - Putrescine - Agmatine G→propionyl-CoA methionine→ S-Adenosyl methionine - S-Adenosyl-L-homocysteine - Homocysteine - Cystathionine - alpha-Ketobutyric acid isoleucine→ 2,3-Dihydroxy-3-methylpentanoic acid - 2-Methylbutyryl-CoA - Tiglyl-CoA - 2-methylacetoacetyl-CoA valine→ Alpha-ketoisovalerate - Isobutyryl-CoA - Methacrylyl-CoA - 3-Hydroxyisobutyryl-CoA - 3-Hydroxyisobutyrate - 2-methyl-3-oxopropanoate threonine→ Alpha-ketobutyric acid propionyl-CoA→ Methylmalonyl-CoA G→fumarate phenylalanine→tyrosine→ 4-Hydroxyphenylpyruvic acid - Homogentisic acid - 4-Maleylacetoacetate Other cysteine+glutamate→glutathione gamma-Glutamylcysteine glycine→creatine Glycocyamine - Phosphocreatine - Creatinine Other Glycerate 3-phosphate (serine) - Cysteine sulfinic acid see also enzymes, disorders