Methylcobalamin

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Methylcobalamin
Systematic (IUPAC) name
?
Identifiers
CAS number	13422-55-4
ATC code	B03BA05
PubChem	6436232
Chemical data
Formula	C63H91CoN13O14P
Mol. mass	1344.40 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	oral,subliungal,injection.

Methylcobalamin is a cobalamin (MeB₁₂) used in peripheral neuropathy, diabetic neuropathy etc. It is a form of vitamin B₁₂. It has been studied in conjunction with sleep-wake rhythm disorders, where it appears to yield benefits, but at a low or inconsistent level.^[1]

It is used in vitamin B12 deficiency (pernicious anemia) treatment.

[edit] See also

• ATC code B03
• Arakawa's syndrome II

[edit] References

1. ^ Double-blind test on the efficacy of methylcobalamin on sleep-wake rhythm disorders

v • d • e Vitamins (A11) Fat soluble A: Retinol - Beta-carotene - Tretinoin - Alpha-carotene D: 7-Dehydrocholesterol → Previtamin D3 → Cholecalciferol (D3) → Calcidiol → Calcitriol (active form) → Calcitroic acid; Ergosterol → Ergocalciferol (D2); (analogues: Dihydrotachysterol, Calcipotriol, Tacalcitol) E: Tocopherol - Tocotrienol K: Naphthoquinone - Phylloquinone/K1 - Menatetrenone/K2 Water soluble: B vitamins B1 (Thiamine, Sulbutiamine, Benfotiamine) - B2 (Riboflavin) - B3 (Niacin, Nicotinamide) - B5 (Pantothenic acid, Dexpanthenol, Pantethine) - B6 (Pyridoxine, Pyridoxal phosphate) - B7 (Biotin) - B9 (Folic acid) - B12 (Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide) Water soluble: other C (Ascorbic acid) - Choline see also enzyme cofactors

v • d • e Types of enzyme cofactors Coenzymes vitamins: NAD+ (B3) - NADP+ (B3) - Coenzyme A (B5) - Tetrahydrofolic acid (B9)/Dihydrofolic acid/5,10-Methylenetetrahydrofolate - Menaquinone (K) - Ascorbic acid (C) - Coenzyme F420 Adenosine triphosphate - S-Adenosyl methionine - 3'-Phosphoadenosine-5'-phosphosulfate - Coenzyme Q - Tetrahydrobiopterin - Cytidine triphosphate - Glutathione - Coenzyme M - Coenzyme B - Methanofuran - Tetrahydromethanopterin Prosthetic groups: Organic group vitamins: Thiamine pyrophosphate (B1) - Flavin mononucleotide (B2) - Flavin adenine dinucleotide (B2) - Pyridoxal phosphate (B6) - Biotin (B7) - Methylcobalamin (B12) - Cobamamide (B12) Pyrroloquinoline quinone - Heme - Molybdopterin - Lipoic acid Prosthetic groups: Metals Calcium - Selenium - Copper - Iron - Magnesium - Manganese - Nickel - Zinc - Molybdenum