Dihydrotachysterol

From Wikipedia, the free encyclopedia

Dihydrotachysterol
Systematic (IUPAC) name
(1S,3E,4S)-3-[(2E)-2-[(1R,3aS,7aR)-1- [(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-7a-methyl- 2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]- 4-methylcyclohexan-1-ol
Identifiers
CAS number	67-96-9
ATC code	A11CC02
PubChem	5311071
DrugBank	APRD00143
Chemical data
Formula	C28H46O
Mol. mass	398.664 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	>99%
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Dihydrotachysterol (DHT) is a synthetic vitamin D analog activated in the liver that does not require renal hydroxylation like vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). DHT has a rapid onset of action (2 hours), a shorter half-life, and a greater effect on mineralization of bone salts than does vitamin D.

v • d • e Cholestanes, membrane lipids: sterols Adosterol - Cholecalciferol/Ergocalciferols - Cholesterol - Dihydrotachysterol - Fusidic acid - Lanosterol - Phytosterols - Solanine

v • d • e Vitamins (A11) Fat soluble A: Retinol - Beta-carotene - Tretinoin - Alpha-carotene D: 7-Dehydrocholesterol → Previtamin D3 → Cholecalciferol (D3) → Calcidiol → Calcitriol (active form) → Calcitroic acid; Ergosterol → Ergocalciferol (D2); (analogues: Dihydrotachysterol, Calcipotriol, Tacalcitol) E: Tocopherol - Tocotrienol K: Naphthoquinone - Phylloquinone/K1 - Menatetrenone/K2 Water soluble: B vitamins B1 (Thiamine, Sulbutiamine, Benfotiamine) - B2 (Riboflavin) - B3 (Niacin, Nicotinamide) - B5 (Pantothenic acid, Dexpanthenol, Pantethine) - B6 (Pyridoxine, Pyridoxal phosphate) - B7 (Biotin) - B9 (Folic acid) - B12 (Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide) Water soluble: other C (Ascorbic acid) - Choline see also enzyme cofactors