5,10-Methylenetetrahydrofolate

5,10-Methylenetetrahydrofolate

Identifiers
CAS number	[3432-99-3]
PubChem	108194
MeSH	5,10-methylenetetrahydrofolate
Properties
Molecular formula	C₂₀H₂₃N₇O₆
Molar mass	457.44 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

5,10-Methylenetetrahydrofolate (5,10-CH₂-THF) is the substrate used by methylenetetrahydrofolate reductase to generate 5-methyltetrahydrofolate. This is a coenzyme used in thymidine biosynthesis by thymidylate synthase (FAD).

[edit] See also

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v • d • e Types of enzyme cofactors

Coenzymes	vitamins: NAD⁺ (B3) - NADP⁺ (B3) - Coenzyme A (B5) - Tetrahydrofolic acid (B9)/Dihydrofolic acid/5,10-Methylenetetrahydrofolate - Menaquinone (K) - Ascorbic acid (C) - Coenzyme F420 Adenosine triphosphate - S-Adenosyl methionine - 3'-Phosphoadenosine-5'-phosphosulfate - Coenzyme Q - Tetrahydrobiopterin - Cytidine triphosphate - Glutathione - Coenzyme M - Coenzyme B - Methanofuran - Tetrahydromethanopterin

Prosthetic groups: Organic group	vitamins: Thiamine pyrophosphate (B1) - Flavin mononucleotide (B2) - Flavin adenine dinucleotide (B2) - Pyridoxal phosphate (B6) - Biotin (B7) - Methylcobalamin (B12) - Cobamamide (B12) Pyrroloquinoline quinone - Heme - Molybdopterin - Lipoic acid

Prosthetic groups: Metals	Calcium - Selenium - Copper - Iron - Magnesium - Manganese - Nickel - Zinc - Molybdenum