Thymidylate synthase (FAD)

From Wikipedia, the free encyclopedia

In enzymology, a thymidylate synthase (FAD) (EC 2.1.1.148) is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydrofolate + dUMP + FADH₂ dTMP + tetrahydrofolate + FAD

The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, dUMP, and FADH2, whereas its 3 products are dTMP, tetrahydrofolate, and FAD.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase. Other names in common use include Thy1, and ThyX. This enzyme participates in pyrimidine metabolism and one carbon pool by folate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2AF6, 2CFA, and 2GQ2.

[edit] References

• IUBMB entry for 2.1.1.148
• BRENDA references for 2.1.1.148 (Recommended.)
• PubMed references for 2.1.1.148
• PubMed Central references for 2.1.1.148
• Google Scholar references for 2.1.1.148
• Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U (2002). "An alternative flavin-dependent mechanism for thymidylate synthesis". Science. 297: 105–7. doi:10.1126/science.1072113. PMID 12029065. 

[edit] External links

• IUBMB entry for 2.1.1.148

• KEGG entry for 2.1.1.148

• BRENDA entry for 2.1.1.148

• NiceZyme view of 2.1.1.148

• EC2PDB: PDB structures for 2.1.1.148

• PRIAM entry for 2.1.1.148

• PUMA2 entry for 2.1.1.148

• IntEnz: Integrated Enzyme entry for 2.1.1.148

• MetaCyc entry for 2.1.1.148

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050797: thymidylate synthase (FAD)

• AMIGO entry for GO code 0050797: thymidylate synthase (FAD)