KCNIP2
From Wikipedia, the free encyclopedia
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Kv channel interacting protein 2
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| Identifiers | ||
| Symbol(s) | KCNIP2; DKFZp566L1246; KCHIP2; MGC17241 | |
| External IDs | OMIM: 604661 HomoloGene: 23710 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 30819 | n/a |
| Ensembl | ENSG00000120049 | n/a |
| Uniprot | Q9NS61 | n/a |
| Refseq | NM_014591 (mRNA) NP_055406 (protein) |
n/a (mRNA) n/a (protein) |
| Location | Chr 10: 103.58 - 103.59 Mb | n/a |
| Pubmed search | [1] | n/a |
Kv channel interacting protein 2, also known as KCNIP2, is a human gene.[1]
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.[1]
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[edit] See also
[edit] References
[edit] Further reading
- An WF, Bowlby MR, Betty M, et al. (2000). "Modulation of A-type potassium channels by a family of calcium sensors.". Nature 403 (6769): 553–6. doi:. PMID 10676964.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:. PMID 11230166.
- Ohya S, Morohashi Y, Muraki K, et al. (2001). "Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2.". Biochem. Biophys. Res. Commun. 282 (1): 96–102. doi:. PMID 11263977.
- Bähring R, Dannenberg J, Peters HC, et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating.". J. Biol. Chem. 276 (26): 23888–94. doi:. PMID 11287421.
- Rosati B, Pan Z, Lypen S, et al. (2001). "Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle.". J. Physiol. (Lond.) 533 (Pt 1): 119–25. PMID 11351020.
- Decher N, Uyguner O, Scherer CR, et al. (2002). "hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant.". Cardiovasc. Res. 52 (2): 255–64. PMID 11684073.
- Kuo HC, Cheng CF, Clark RB, et al. (2002). "A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.". Cell 107 (6): 801–13. PMID 11747815.
- Deschênes I, DiSilvestre D, Juang GJ, et al. (2002). "Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?". Circulation 106 (4): 423–9. PMID 12135940.
- Deschênes I, Tomaselli GF (2002). "Modulation of Kv4.3 current by accessory subunits.". FEBS Lett. 528 (1-3): 183–8. PMID 12297301.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Shibata R, Misonou H, Campomanes CR, et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.". J. Biol. Chem. 278 (38): 36445–54. doi:. PMID 12829703.
- Ren X, Shand SH, Takimoto K (2003). "Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide.". J. Biol. Chem. 278 (44): 43564–70. doi:. PMID 12928444.
- Kim LA, Furst J, Butler MH, et al. (2004). "Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.". J. Biol. Chem. 279 (7): 5549–54. doi:. PMID 14623880.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
- Kim LA, Furst J, Gutierrez D, et al. (2004). "Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution.". Neuron 41 (4): 513–9. PMID 14980201.
- Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.". Biochem. Biophys. Res. Commun. 319 (3): 720–4. doi:. PMID 15184042.
- Rhodes KJ, Carroll KI, Sung MA, et al. (2005). "KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.". J. Neurosci. 24 (36): 7903–15. doi:. PMID 15356203.
- Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2.". Biochem. Biophys. Res. Commun. 321 (3): 606–10. doi:. PMID 15358149.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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