HCN1

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Hyperpolarization activated cyclic nucleotide-gated potassium channel 1
PDB rendering based on 1q3e.
Available structures: 1q3e, 1q43, 1q5o
Identifiers
Symbol(s) HCN1; BCNG-1; BCNG1; HAC-2
External IDs OMIM: 602780 MGI: 1096392 HomoloGene: 32093
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 348980 15165
Ensembl ENSG00000164588 ENSMUSG00000021730
Uniprot O60741 O88704
Refseq NM_021072 (mRNA)
NP_066550 (protein)		 NM_010408 (mRNA)
NP_034538 (protein)
Location Chr 5: 45.3 - 45.73 Mb Chr 13: 118.72 - 119.1 Mb
Pubmed search [1] [2]

Hyperpolarization activated cyclic nucleotide-gated potassium channel 1, also known as HCN1, is a human gene.[1]

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM][1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1.

[edit] Further reading

  • Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Santoro B, Grant SG, Bartsch D, Kandel ER (1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14815–20. PMID 9405696. 
  • Santoro B, Liu DT, Yao H, et al. (1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.". Cell 93 (5): 717–29. PMID 9630217. 
  • Ludwig A, Zong X, Jeglitsch M, et al. (1998). "A family of hyperpolarization-activated mammalian cation channels.". Nature 393 (6685): 587–91. doi:10.1038/31255. PMID 9634236. 
  • Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain.". Hum. Genet. 103 (6): 666–73. PMID 9921901. 
  • Ulens C, Tytgat J (2001). "Functional heteromerization of HCN1 and HCN2 pacemaker channels.". J. Biol. Chem. 276 (9): 6069–72. doi:10.1074/jbc.C000738200. PMID 11133998. 
  • Proenza C, Tran N, Angoli D, et al. (2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.". J. Biol. Chem. 277 (33): 29634–42. doi:10.1074/jbc.M200504200. PMID 12034718. 
  • Chaplan SR, Guo HQ, Lee DH, et al. (2003). "Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.". J. Neurosci. 23 (4): 1169–78. PMID 12598605. 
  • Lesso H, Li RA (2003). "Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype.". J. Biol. Chem. 278 (25): 22290–7. doi:10.1074/jbc.M302466200. PMID 12668666. 
  • Bender RA, Soleymani SV, Brewster AL, et al. (2003). "Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.". J. Neurosci. 23 (17): 6826–36. PMID 12890777. 
  • Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 

[edit] External links

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