TRPM8

From Wikipedia, the free encyclopedia

Transient receptor potential cation channel, subfamily M, member 8
Identifiers
Symbol(s)	TRPM8; LTRPC6; MGC2849; TRPP8
External IDs	OMIM: 606678 MGI: 2181435 HomoloGene: 23433
Gene ontology Molecular Function: • ion channel activity • calcium channel activity Cellular Component: • membrane • integral to membrane Biological Process: • ion transport • cellular calcium ion homeostasis • response to cold • response to stimulus • thermoception
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	79054	171382
Ensembl	ENSG00000144481	ENSMUSG00000036251
Uniprot	Q7Z2W7	Q148W9
Refseq	NM_024080 (mRNA) NP_076985 (protein)	NM_134252 (mRNA) NP_599013 (protein)
Location	Chr 2: 234.49 - 234.59 Mb	Chr 1: 90.15 - 90.22 Mb
Pubmed search	[1]	[2]

Transient receptor potential cation channel, subfamily M, member 8, also known as TRPM8, is a human gene. The TRPM8 protein is expresed in sensory neurons, and it is activated by cold temperatures and cooling agents, such as menthol and icilin where as CPS-369 is the most selective agonist of TRPM8^[1]. TRPM8 is an ion channel, upon activation it allows the entry of Na⁺ (sodium) and Ca²⁺ (calcium) ions to the cell that leads to depolarization and the generation of action potential. This eventually leads to the feeling of cold. Cold-patches have traditionally been used to induce analgesia or relief in pain which is caused as result of traumatic injuries. The underlying mechanism of cold-induced analgesia remained obscure till the discovery of TRPM8. Three independent research groups have reported that mice lacking TRPM8 gene are severely impaired in their ability to detect cold temperatures. Remarkably, these animals are deficient in many diverse aspects of cold signaling, including cool and noxious cold perception, injury-evoked sensitization to cold, and cooling-induced analgesia. These animals provide a great deal of insight into the molecular signaling pathways that participate in the detection of cold and painful stimuli. Many groups are now actively involved in looking for selective TRPM8 ligands to be used as new generation of neuropathic analgesic drugs.

Contents 1 See also 2 References 3 Further reading 4 External links

[edit] See also

• TRPM

[edit] References

[edit] Further reading

[edit] External links

• MeSH TRPM8+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels Ca2+: Calcium channel Voltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, α2δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel Na+: Sodium channel Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel K+: Potassium channel Voltage-gated (Kvα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • Kvβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier Kir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17) Cl-: Chloride channel Cystic fibrosis transmembrane conductance regulator Porin Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1) Cations: TRP TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6) Other/general Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel