KCNJ8

From Wikipedia, the free encyclopedia

Potassium inwardly-rectifying channel, subfamily J, member 8

Identifiers

KCNJ8; KIR6.1; uKATP-1

External IDs

OMIM: 600935 MGI: 1100508 HomoloGene: 3654

Gene ontology
Molecular Function:	• voltage-gated ion channel activity • ATP-activated inward rectifier potassium channel activity • potassium ion binding
Cellular Component:	• membrane fraction • voltage-gated potassium channel complex • membrane • integral to membrane • myofibril
Biological Process:	• ion transport • potassium ion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004982 (mRNA)
NP_004973 (protein)

NM_008428 (mRNA)
NP_032454 (protein)

Location

Chr 12: 21.81 - 21.82 Mb

Chr 6: 142.52 - 142.53 Mb

Pubmed search

[1]

[2]

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8 or K_IR6.1, is a human gene.^[1]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Inward-rectifier potassium ion channel

[edit] References

^ ^a ^b Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8.

[edit] Further reading

Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
Inagaki N, Tsuura Y, Namba N, et al. (1995). "Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart.". J. Biol. Chem. 270 (11): 5691–4. PMID 7890693.
Inagaki N, Inazawa J, Seino S (1996). "cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8).". Genomics 30 (1): 102–4. doi:10.1006/geno.1995.0018. PMID 8595887.
Suzuki M, Kotake K, Fujikura K, et al. (1998). "Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria.". Biochem. Biophys. Res. Commun. 241 (3): 693–7. doi:10.1006/bbrc.1997.7891. PMID 9434770.
Erginel-Unaltuna N, Yang WP, Blanar MA (1998). "Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel.". Gene 211 (1): 71–8. PMID 9573340.
Surah-Narwal S, Xu SZ, McHugh D, et al. (1999). "Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A.". Br. J. Pharmacol. 128 (3): 667–72. doi:10.1038/sj.bjp.0702862. PMID 10516647.
Tucker SJ, Ashcroft FM (1999). "Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.". J. Biol. Chem. 274 (47): 33393–7. PMID 10559219.
Kono Y, Horie M, Takano M, et al. (2001). "The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A.". Pflugers Arch. 440 (5): 692–8. PMID 11007308.
Cui Y, Giblin JP, Clapp LH, Tinker A (2001). "A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits.". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 729–34. doi:10.1073/pnas.011370498. PMID 11136227.
Liu Y, Ren G, O'Rourke B, et al. (2001). "Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.". Mol. Pharmacol. 59 (2): 225–30. PMID 11160857.
Giblin JP, Cui Y, Clapp LH, Tinker A (2002). "Assembly limits the pharmacological complexity of ATP-sensitive potassium channels.". J. Biol. Chem. 277 (16): 13717–23. doi:10.1074/jbc.M112209200. PMID 11825905.
Vanoye CG, MacGregor GG, Dong K, et al. (2002). "The carboxyl termini of K(ATP) channels bind nucleotides.". J. Biol. Chem. 277 (26): 23260–70. doi:10.1074/jbc.M112004200. PMID 11956191.
Miki T, Suzuki M, Shibasaki T, et al. (2002). "Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1.". Nat. Med. 8 (5): 466–72. doi:10.1038/nm0502-466. PMID 11984590.
Nakamura K, Hirano J, Itazawa S, Kubokawa M (2002). "Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells.". Am. J. Physiol. Renal Physiol. 283 (4): F784–91. doi:10.1152/ajprenal.00023.2002. PMID 12217870.
Curley M, Cairns MT, Friel AM, et al. (2003). "Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium.". Mol. Hum. Reprod. 8 (10): 941–5. PMID 12356945.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Singh H, Hudman D, Lawrence CL, et al. (2004). "Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes.". J. Mol. Cell. Cardiol. 35 (5): 445–59. PMID 12738227.
Insuk SO, Chae MR, Choi JW, et al. (2003). "Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells.". Int. J. Impot. Res. 15 (4): 258–66. doi:10.1038/sj.ijir.3901013. PMID 12934053.
Emanuele E, Falcone C, Carabela M, et al. (2004). "Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion.". Int. J. Mol. Med. 12 (4): 509–12. PMID 12964027.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

[edit] External links

MeSH KCNJ8+protein,+human

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v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel