HCN2

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Hyperpolarization activated cyclic nucleotide-gated potassium channel 2
PDB rendering based on 1q3e.
Available structures: 1q3e, 1q43, 1q5o
Identifiers
Symbol(s) HCN2; BCNG-2; BCNG2; HAC-1
External IDs OMIM: 602781 MGI: 1298210 HomoloGene: 31022
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 610 15166
Ensembl ENSG00000099822 ENSMUSG00000020331
Uniprot Q9UL51 O88703
Refseq NM_001194 (mRNA)
NP_001185 (protein)		 XM_985431 (mRNA)
XP_990525 (protein)
Location Chr 19: 0.54 - 0.57 Mb Chr 10: 79.12 - 79.14 Mb
Pubmed search [1] [2]

Hyperpolarization activated cyclic nucleotide-gated potassium channel 2, also known as HCN2, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2.

[edit] Further reading

  • Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.". Pharmacol. Rev. 57 (4): 455-62. doi:10.1124/pr.57.4.8. PMID 16382102. 
  • Santoro B, Grant SG, Bartsch D, Kandel ER (1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14815-20. PMID 9405696. 
  • Santoro B, Liu DT, Yao H, et al. (1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.". Cell 93 (5): 717-29. PMID 9630217. 
  • Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain.". Hum. Genet. 103 (6): 666-73. PMID 9921901. 
  • Ludwig A, Zong X, Stieber J, et al. (1999). "Two pacemaker channels from human heart with profoundly different activation kinetics.". EMBO J. 18 (9): 2323-9. doi:10.1093/emboj/18.9.2323. PMID 10228147. 
  • Vaccari T, Moroni A, Rocchi M, et al. (1999). "The human gene coding for HCN2, a pacemaker channel of the heart.". Biochim. Biophys. Acta 1446 (3): 419-25. PMID 10524219. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Ulens C, Tytgat J (2001). "Functional heteromerization of HCN1 and HCN2 pacemaker channels.". J. Biol. Chem. 276 (9): 6069-72. doi:10.1074/jbc.C000738200. PMID 11133998. 
  • Proenza C, Tran N, Angoli D, et al. (2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.". J. Biol. Chem. 277 (33): 29634-42. doi:10.1074/jbc.M200504200. PMID 12034718. 
  • Qu J, Altomare C, Bucchi A, et al. (2003). "Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.". Pflugers Arch. 444 (5): 597-601. doi:10.1007/s00424-002-0860-7. PMID 12194012. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sesti F, Rajan S, Gonzalez-Colaso R, et al. (2003). "Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel.". Nat. Neurosci. 6 (4): 353-61. doi:10.1038/nn1028. PMID 12640457. 
  • Stieber J, Thomer A, Much B, et al. (2003). "Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.". J. Biol. Chem. 278 (36): 33672-80. doi:10.1074/jbc.M305318200. PMID 12813043. 
  • Bender RA, Soleymani SV, Brewster AL, et al. (2003). "Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.". J. Neurosci. 23 (17): 6826-36. PMID 12890777. 
  • Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.". J. Biol. Chem. 278 (44): 43781-6. doi:10.1074/jbc.M306958200. PMID 12928435. 
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824. 
  • Michels G, Er F, Khan I, et al. (2005). "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.". Circulation 111 (4): 399-404. doi:10.1161/01.CIR.0000153799.65783.3A. PMID 15687126. 
  • Akhavan A, Atanasiu R, Noguchi T, et al. (2005). "Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization.". J. Cell. Sci. 118 (Pt 13): 2803-12. doi:10.1242/jcs.02423. PMID 15961404. 
  • Calloe K, Elmedyb P, Olesen SP, et al. (2006). "Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.". Biophys. J. 89 (3): 2159-69. doi:10.1529/biophysj.105.063792. PMID 15980171. 

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