TRPV2

From Wikipedia, the free encyclopedia

Transient receptor potential cation channel, subfamily V, member 2

PDB rendering based on 2f37.

Available structures: 2eta, 2etb, 2etc, 2f37

Identifiers

Symbol(s)

TRPV2; MGC12549; VRL; VRL-1; VRL1

External IDs

OMIM: 606676 MGI: 1341836 HomoloGene: 7993

Gene ontology
Molecular Function:	• ion channel activity • calcium channel activity • calcium ion binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• ion transport • calcium ion transport • sensory perception

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016113 (mRNA)
NP_057197 (protein)

NM_011706 (mRNA)
NP_035836 (protein)

Location

Chr 17: 16.26 - 16.28 Mb

Chr 11: 62.39 - 62.42 Mb

Pubmed search

[1]

[2]

Transient receptor potential cation channel, subfamily V, member 2, also known as TRPV2, is a human gene.

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

TRPV

[edit] References

^ Entrez Gene: TRPV2 transient receptor potential cation channel, subfamily V, member 2.

[edit] Further reading

Tominaga M, Julius D (2000). "Capsaicin receptor in the pain pathway.". Jpn. J. Pharmacol. 83 (1): 20–4. PMID 10887936.
Benham CD, Gunthorpe MJ, Davis JB (2004). "TRPV channels as temperature sensors.". Cell Calcium 33 (5-6): 479–87. PMID 12765693.
Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes.". Cell Calcium 33 (5-6): 533–40. PMID 12765698.
Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.

[edit] External links

MeSH TRPV2+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel

TRPV2

From Wikipedia, the free encyclopedia

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[edit] See also

[edit] References

[edit] Further reading

[edit] External links

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