TRPC5

Transient receptor potential cation channel, subfamily C, member 5

Identifiers

External IDs

Gene ontology
Molecular Function:	• ion channel activity • calcium ion binding • protein binding • store-operated calcium channel activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• ion transport • calcium ion transport • nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012471 (mRNA)
NP_036603 (protein)

NM_009428 (mRNA)
NP_033454 (protein)

Location

Pubmed search

Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is subtype of the TRPC family of mammalian transient receptor potential ion channels. Homomultimeric TRP5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin ^[1]. This activation probably plays a role in rheumatoid arthritis.

[edit] See also

Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427-50. doi:10.1124/pr.57.4.6. PMID 16382100.
Beech DJ (2007). "Canonical transient receptor potential 5.". Handb Exp Pharmacol (179): 109-23. doi:10.1007/978-3-540-34891-7_6. PMID 17217053.
Beech DJ (2007). "Bipolar phospholipid sensing by TRPC5 calcium channel.". Biochem. Soc. Trans. 35 (Pt 1): 101-4. doi:10.1042/BST0350101. PMID 17233612.

^ S. H. Xu, P. Sukumar, F. Zeng et al. (2008). "TRPC channel activation by extracellular thioredoxin". Nature 7174: 69-72. doi:10.1038/nature06414. PMID 18172497.

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v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel