Indoprofen
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Indoprofen
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| Systematic (IUPAC) name | |
| 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]propanoic acid |
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| Identifiers | |
| CAS number | |
| ATC code | M01 |
| PubChem | |
| Chemical data | |
| Formula | C17H15NO3 |
| Mol. mass | 281.306 g/mol |
| Pharmacokinetic data | |
| Bioavailability | High (rapid and complete absorption) |
| Metabolism | Glucuronidation |
| Half life | 2.3 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Withdrawn |
| Routes | Oral |
Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]
A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]
[edit] References
- ^ a b Frazin, Natalie (March 9, 2005). Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy. United States National Institute of Neurological Disorders and Stroke. Retrieved on 2007-10-06.
- ^ Lunn MR, Root DE, Martino AM, et al (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol 11 (11): 1489–93. doi:. PMID 15555999.
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