Fenoprofen
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Fenoprofen
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| Systematic (IUPAC) name | |
| 2-[3-(phenoxy)phenyl]propanoic acid | |
| Identifiers | |
| CAS number | ? |
| ATC code | M01 |
| PubChem | |
| Chemical data | |
| Formula | C15H14O3 |
| Mol. mass | 242.26986 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide. |
| Half life | The t ½ is 3 h |
| Excretion | Approximately 90% is renally eliminated. |
| Therapeutic considerations | |
| Pregnancy cat. |
C |
| Legal status | |
| Routes | oral |
Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain.
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[edit] Pharmacology
Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.
[edit] Contraindications
History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
[edit] Drug Interactions
Aminoglycosides (eg, gentamicin): Plasma aminoglycoside levels may be elevated.
Angiotensin-converting enzyme (ACE) inhibitors: Antihypertensive effect of ACE inhibitors may be diminished.
Anticoagulants: Coadministration may prolong PT.
Aspirin: Fenoprofen Cl may be increased; coadministration is not recommended.
Diuretics: Patients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides.
Hydantoins, sulfonamides, sulfonylureas: Fenoprofen may displace these drugs from their binding site.
Lithium: Renal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity.
Methotrexate: May increase methotrexate levels.
Phenobarbital: May decrease fenoprofen t ½ . Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn.
SSRIs (eg, fluoxetine, citalopram): The risk of GI effects may be increased.
[edit] Laboratory Test Interactions
False elevation in free and total serum T 3 as measured by Amerlex-M kit.
[edit] Brand names
- UK - Fenopron (Typharm Limited)
[edit] References
Fenoprofen info from Drugs.com
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