Flurbiprofen

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Flurbiprofen
Systematic (IUPAC) name
2-(3-fluoro-4-phenyl-phenyl)propanoic acid
Identifiers
CAS number 5104-49-4
ATC code M01AE09 M02AA19, S01BC04
PubChem 3394
DrugBank APRD00753
Chemical data
Formula C15H13FO2 
Mol. mass 244.261 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding > 99%
Metabolism Hepatic (CYP2C9)
Half life 4.7-5.7 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C (U.S.), B2 (Au)
Legal status

POM
Routes Oral

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis. It is known by the following tradenames: Ansaid, marketed by Pfizer, and Froben, by Abbott.

Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges.

The single enantiomer of racemate flurbiprofen, tarenflurbil (R-flurbiprofen), is currently in clinical trials for the treatment of metastatic prostate cancer and Alzheimer's disease.


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Anti-inflammatory and antirheumatic products (M01)
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Acetic acid derivatives and related substances: · Aceclofenac · Acemetacin · Alclofenac · Bromfenac · Bumadizone · Bufexamac · Diclofenac · Difenpiramide · Etodolac · Fentiazac · Indometacin · Ketorolac · Lonazolac · Oxametacin · Proglumetacin · Sulindac · Tolmetin · Zomepirac ·

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Propionic acid derivatives: · Alminoprofen · Benoxaprofen · Dexibuprofen · Dexketoprofen · Fenbufen · Fenoprofen · Flunoxaprofen · Flurbiprofen · Ibuprofen · Ibuproxam · Indoprofen · Ketoprofen · Naproxen · Oxaprozin · Pirprofen · Suprofen · Tiaprofenic acid ·

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other anti-inflammatory and antirheumatic agents, non-steroids: · Nabumetone · Niflumic acid · Azapropazone · Glucosamine · Benzydamine · Glycosaminoglycan · Magnesium salicylate · Proquazone · Superoxide dismutase/Orgotein · Nimesulide · Feprazone · Diacerein · Morniflumate · Tenidap · Oxaceprol · Chondroitin sulfate ·
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