Proglumetacin
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Proglumetacin
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| Systematic (IUPAC) name | |
| 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2- methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl] propyl 4-(benzoylamino)-5-(dipropylamino)- 5-oxopentanoate |
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| Identifiers | |
| CAS number | 59209-40-4 (maleate) |
| ATC code | M01 |
| PubChem | |
| Chemical data | |
| Formula | C46H58ClN5O8 |
| Mol. mass | 844.43442 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic. Undergoes enterohepatic recirculation |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.
[edit] References
- ^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267.
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