Triamcinolone

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Triamcinolone
Systematic (IUPAC) name
9-fluoro-11,16,17-trihydroxy-17- (2-hydroxyacetyl) -10,13-dimethyl-6,7,8,9,10,11,12, 13,14,15,16,17- dodecahydrocyclopenta[a]phenanthren-3-one
Identifiers
CAS number	124-94-7
ATC code	A01AC01 D07AB09, D07XB02, H02AB08, R01AD11, R03BA06, S01BA05
PubChem	31307
DrugBank	APRD00422
Chemical data
Formula	C21H27FO6
Mol. mass	394.434 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Protein binding	68%
Metabolism	Hepatic
Half life	88 minutes
Excretion	Fecal and renal
Therapeutic considerations
Pregnancy cat.	A (Au), C (US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral, topical, IM, intra-articular, intrasynovial

Triamcinolone (trade names Kenalog, Aristocort, Nasacort, Tri-Nasal, Triderm, Azmacort, Trilone, Volon A, Tristoject, Fougera, Tricortone,Triesence;) is a synthetic corticosteroid given orally, by injection, inhalation, or as a topical ointment or cream.

[edit] Uses

Triamcinolone is used in the post-operative period of certain cosmetic surgery procedures, notably rhinoplasty. Injected into the subcutaneous area, it may help to alleviate stubborn swelling and decrease the presence of scar tissue.

Topical triamcinolone acetonide paste is often prescribed for mouth or gum irritation following dental procedures.

Triamcinolone is occasionally used to treat severe cases of hayfever.^[1]

The drug may also be used to treat diabetic retinopathy.^{[citation needed]} For the most severe cases of eczema, it is a highly effective treatment but may require a waiting period before subsequent treatments.^{[citation needed]}

[edit] Forms

Different triamcinolone salts are available, including acetonide, hexacetonide and diacetate.

Triamcinolone acetonide is a more potent type of triamcinolone, being about 8 times as effective as prednisone.

[edit] Side effects

Side effects of Triamcinolone include a sore throat, nosebleeds, increased coughing, headache, and runny nose. White patches in the throat or nose indicates a serious side effect. Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing.^[2]

[edit] References

1. ^ Hayfever (allergic rhinitis) - BUPA
2. ^ Drugs and Treatments - Nasacort AQ Nasl - Patient Handout. WebMD. Retrieved on 2008-03-24.

[edit] External links

• MedlinePlus DrugInfo medmaster-a601124

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