Levocabastine

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Levocabastine
Systematic (IUPAC) name
1-[4-cyano-4-(4-fluorophenyl)-cyclohexyl]- 3-methyl-4-phenyl-piperidine-4- carboxylic acid
Identifiers
CAS number	79516-68-0
ATC code	R01AC02 S01GX02
PubChem	54385
DrugBank	APRD01069
Chemical data
Formula	C26H29FN2O2
Mol. mass	420.519 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	3
Excretion	?
Therapeutic considerations
Pregnancy cat.	B3(AU) C(US)
Legal status	℞ Prescription only
Routes	Ophthalmic, intranasal[1]

Levocabastine is a selective second-generation H₁-receptor antagonist used for allergic conjunctivitis.

Levocabastine was discovered at Janssen Pharmaceutica in 1979.

[edit] References

• Pipkorn U, Bende M, Hedner J, Hedner T., A double-blind evaluation of topical levocabastine, a new specific H1 antagonist in patients with allergic conjunctivitis, Allergy. 1985 Oct;40(7):491-6.
• RxList (2004). Livostin Online, Description, Chemistry, Ingredients - Levocabastine. LIVOSTIN. RxList Inc. Retrieved on 9 October 2005.
• Novartis Pharmaceuticals (March 2002). LIVOSTIN (PDF). Retrieved on August 20, 2006.

1. ^  RxMed: Pharmaceutical Information - LIVOSTIN NASAL SPRAY. Retrieved on 13 November 2005.

v • d • e Decongestants and other nasal preparations (R01) Topical: sympathomimetics, plain Cyclopentamine - Ephedrine - Phenylephrine - Oxymetazoline - Tetryzoline - Xylometazoline - Naphazoline - Tramazoline - Metizoline - Tuaminoheptane - Fenoxazoline - Tymazoline - Epinephrine Topical: antiallergic agents, excluding corticosteroids Cromoglicic acid - Levocabastine - Azelastine - Antazoline - Spaglumic acid - Thonzylamine - Nedocromil - Olopatadine Topical: corticosteroids Beclometasone - Prednisolone - Dexamethasone - Flunisolide - Budesonide - Betamethasone - Tixocortol - Fluticasone - Mometasone furoate - Triamcinolone - Ciclesonide Topical: other nasal preparations Calcium hexamine thiocyanate - Retinol - Ipratropium bromide - Ritiometan - Mupirocin - Hexamidine - Framycetin Systemic use: Sympathomimetics Phenylpropanolamine - Pseudoephedrine - Phenylephrine