Temafloxacin

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Temafloxacin
Systematic (IUPAC) name
1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Identifiers
CAS number  ?
ATC code  ?
PubChem 60021
Chemical data
Formula C21H18F3N3O3 
Mol. mass 417.381 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

Withdrawn
Routes Oral

Temafloxacin (marketed by Abbott Laboratories as Omniflox), is a fluoroquinolone antibiotic drug which was withdrawn from sale in the U.S. shortly after its approval in 1992 because of serious adverse reactions resulting in three deaths.

Omniflox was approved to treat lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections in the U.S. by the Food and Drug Administration in January 1992. Severe adverse reactions, including allergic reactions and hemolytic anemia, developed in about fifty patients during the first four months of its use, leading to three patient deaths. Abbott withdrew the drug from sale in June 1992.

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Antibacterials for systemic use: quinolones (J01M)
Fluoroquinolones
Alatrofloxacin‡ • Ciprofloxacin • Danofloxacin§ • Difloxacin§ • Enoxacin • Enrofloxacin§ • Fleroxacin‡ • Garenoxacin • Gatifloxacin • Gemifloxacin • Grepafloxacin‡ • Ibafloxacin§ • Levofloxacin • Lomefloxacin • Marbofloxacin§ • Moxifloxacin • Norfloxacin • Ofloxacin • Orbifloxacin§ • Pazufloxacin • Pefloxacin • Pradofloxacin§ • Prulifloxacin • Rufloxacin • Sarafloxacin§ • Sitafloxacin† • Sparfloxacin • Temafloxacin‡ • Tosufloxacin • Trovafloxacin‡
Other quinolones
†Undergoing clinical trials. ‡ Withdrawn from market. § Veterinary use medications.
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