Prulifloxacin

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Prulifloxacin
Systematic (IUPAC) name
 ?
Identifiers
CAS number  ?
ATC code J01MA17
PubChem 65947
Chemical data
Formula C21H20FN3O6S 
Mol. mass 461.463403 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism By esterases, to ulifloxacin
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes Oral

Prulifloxacin (INN) is a broad-spectrum fluoroquinolone antibiotic. It is a prodrug, and is metabolized in the body to the active compound ulifloxacin. Prulifloxacin has a long half-life and may therefore be taken only once a day.[1]

In clinical trials, prulifloxacin appeared as effective as ciprofloxacin, co-amoxiclav or pefloxacin in the treatment of bronchitis exacerbations or lower urinary tract infections. It was tolerated as well as ciprofloxacin.[1]

[edit] References

  1. ^ a b Keam SJ, Perry CM (2004). "Prulifloxacin". Drugs 64 (19): 2221–34; discussion 2235–6. PMID 15456336. 
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v • d • e
Antibacterials for systemic use: quinolones (J01M)
Fluoroquinolones
Alatrofloxacin‡ • Ciprofloxacin • Danofloxacin§ • Difloxacin§ • Enoxacin • Enrofloxacin§ • Fleroxacin‡ • Garenoxacin • Gatifloxacin • Gemifloxacin • Grepafloxacin‡ • Ibafloxacin§ • Levofloxacin • Lomefloxacin • Marbofloxacin§ • Moxifloxacin • Norfloxacin • Ofloxacin • Orbifloxacin§ • Pazufloxacin • Pefloxacin • Pradofloxacin§ • Prulifloxacin • Rufloxacin • Sarafloxacin§ • Sitafloxacin† • Sparfloxacin • Temafloxacin‡ • Tosufloxacin • Trovafloxacin‡
Other quinolones
†Undergoing clinical trials. ‡ Withdrawn from market. § Veterinary use medications.