Semorphone

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Semorphone
Systematic (IUPAC) name
(5α)-4,6-Epoxy-3,14-dihydroxy-17-(2-methoxyethyl)morphinan-6-one
Identifiers
CAS number	88939-40-6
ATC code	?
PubChem	5491906
Chemical data
Formula	C19H23NO5
Mol. mass	345.39 g/mol
Synonyms	Semorphone, Mr 2264
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Semorphone (Mr 2264) is an opiate analogue that is an N-substituted derivative of oxymorphone.

Semorphone is a partial agonist at μ-opioid receptors. It is around twice the potency of morphine, but with a ceiling effect on both analgesia and respiratory depression^[1] which means that these effects stop becoming any stronger after a certain maximum dose.

It is not currently used in medicine, and is not a controlled drug, although it might be considered to be a controlled substance analogue of oxymorphone on the grounds of its related chemical structure in some jurisdictions such as the USA, Canada, Australia and New Zealand.

[edit] References

1. ^ Behne M, Bremerich D, Heinrich J, Schumacher H, Scherer M. Respiratory effects and tolerability of Mr 2264 Cl. A new opiate partial agonist in comparison with morphine and placebo. European Journal of Clinical Pharmacology. 1994;46(4):301-4.

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