Ethoheptazine

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Ethoheptazine
Systematic (IUPAC) name
ethyl 1-methyl-4-phenylazepane-4-carboxylate
Identifiers
CAS number	77-15-6
ATC code	?
PubChem	6469
Chemical data
Formula	C16H23NO2
Mol. mass	261.36 g/mol
Synonyms	Ethoheptazine, Zactane, Equagesic
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Schedule V(US)
Routes	?

Ethoheptazine (Zactane, Equagesic) is an opioid analgesic from the phenazepine family. It was invented in the 1950s^[1] and is related to other drugs such as proheptazine.^[2]

Ethoheptazine produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.^[3] It was sold by itself as Zactane, and is still available as a combination product with acetylsalicylic acid and meprobamate as Equagesic, which is used for the treatment of conditions where both pain and anxiety are present.^[4][1]

[edit] References

1. ^ Batterman RC, Golbey M, Grossman AJ, Leifer P. Analgesic effectiveness of orally administered ethoheptazine in man. American Journal of Medical Sciences. 1957 Oct;234(4):413-9.
2. ^ Diamond J, Bruce WF, Tyson FT. Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine). Journal of Medicinal Chemistry. 1964 Jan;7:57-60.
3. ^ Cinelli P, Zucchini M. Current pharmaco-therapeutic possiblities in the treatment of pain. Experiments with ethoeptazine. (Italian). Minerva Medica. 1962 Mar 3;53:637-42.
4. ^ Scheiner JJ, Richards DJ. Treatment of musculoskeletal pain and associated anxiety with an ethoheptazine-aspirin-meprobamate combination (equagesic): a controlled study. Current Therapeutic Research, Clinical and Experimental. 1974 Sep;16(9):928-36.

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