DPI-3290

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DPI-3290
Systematic (IUPAC) name
(+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide
Identifiers
CAS number	?
ATC code	?
PubChem	5242141
Chemical data
Formula	C30H34FN3O2
Mol. mass	487.607 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

DPI-3290 is a drug which is used in scientific research. It is a potent analgesic drug,^[1] which produces little respiratory depression.^[2]

DPI-3290 acts as an agonist at both μ- and δ-opioid receptors, with an IC50 of 6.2nM at μ and 1.0nM at δ.^[3]

[edit] References

1. ^ Gengo PJ, Pettit HO, O'Neill SJ, Wei K, McNutt R, Bishop MJ, Chang KJ. DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. Journal of Pharmacology and Experimental Therapeutics. 2003 Dec;307(3):1221-6. PMID 14534368
2. ^ Gengo PJ, Pettit HO, O'Neill SJ, Su YF, McNutt R, Chang KJ. DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function. Journal of Pharmacology and Experimental Therapeutics. 2003 Dec;307(3):1227-33. PMID 14534367
3. ^ Ananthan S. Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics. AAPS Journal. 2006 Mar 10;8(1):E118-25. PMID 16584118

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