IC-26

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IC-26
Systematic (IUPAC) name
4-ethylsulfonyl-N,N-dimethyl-4,4-di(phenyl)butan-2-amine
Identifiers
CAS number	?
ATC code	?
PubChem	113832
Chemical data
Formula	C20H27NO2S
Mol. mass	345.499
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

IC-26 (WIN 1161-3) is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group.

Human and animal studies suggest that IC-26 is around the same potency as methadone,^[1][2] although other studies have found its activity to be inconsistent between different patients, with consistent opioid activity only being seen at a dose several times that of methadone. IC-26 was assessed for its abuse potantial, but despite being found to have similar potential to methadone for development of dependence^[3] it was never placed under international control as an illegal drug.

[edit] References

1. ^ Daniel Lednicer. Central Analgetics. (1982), p194. ISBN 0-471-08314-3
2. ^ Paul A J Janssen. Synthetic Analgesics Part 1: Diphenylpropylamines. Pergamon Press 1960. p161-163.
3. ^ Wolbach AB, Fraser HF. Addiction Liability of I-C-26. UNODC Bulletin on Narcotics 1963 Vol 1

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