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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 05:00, 10 November 2007 (UTC)
[edit] Proteins without matches (19)
[edit] Proteins with a High Potential Match (6)
[edit] Created (13)
[edit] Manual Inspection (Page not found) (12)
[edit] Protein Status Grid - Date: 05:00, 10 November 2007 (UTC)
| HUGO Symbol |
Action Summary |
Target page(s) |
WP Symbol Search |
| COL5A1 |
Manual Inspection (Page not found) |
Other Pages: Collagen (Unknown Data); COL5A1 (Redirect -> Type-V collagen); Type-V collagen (Protein Template); |
[1] |
| RCC1 |
Created |
Other Pages: Regulator of chromosome condensation 1 (No Data); RCC1 (No Data); CHC1 (No Data); Chc1 (No Data); RCC1-I (No Data); Rcc1-i (No Data); |
[2] |
| DSG3 |
Manual Inspection (Page not found) |
Other Pages: Desmoglein 3 (Redirect -> Desmoglein); DSG3 (No Data); CDHF6 (No Data); Cdhf6 (No Data); DKFZp686P23184 (No Data); Dkfzp686p23184 (No Data); PVA (DisAmbig); Pva (No Data); Desmoglein (Protein Template); |
[3] |
| DDB2 |
Created |
Other Pages: Damage-specific DNA binding protein 2 (No Data); DDB2 (No Data); FLJ34321 (No Data); Flj34321 (No Data); |
[4] |
| FST |
Manual Inspection (Page not found) |
Other Pages: Follistatin (Protein Template); FST (DisAmbig); FS (DisAmbig); Fs (Redirect -> FS); |
[5] |
| TPH2 |
Created |
Other Pages: Tryptophan hydroxylase 2 (No Data); TPH2 (No Data); FLJ37295 (No Data); Flj37295 (No Data); MGC138871 (No Data); Mgc138871 (No Data); MGC138872 (No Data); Mgc138872 (No Data); NTPH (No Data); Ntph (No Data); |
[6] |
| CYP11B1 |
Manual Inspection (Page not found) |
Other Pages: Cytochrome P450 (Unknown Data); CYP11B1 (Redirect -> Steroid 11-beta-hydroxylase); CPN1 (No Data); Cpn1 (No Data); CYP11B (No Data); Cyp11b (No Data); DKFZp686B05283 (No Data); Dkfzp686b05283 (No Data); FHI (DisAmbig); Fhi (No Data); FLJ36771 (No Data); Flj36771 (No Data); P450C11 (No Data); P450c11 (No Data); Steroid 11-beta-hydroxylase (Protein Template); |
[7] |
| DLG3 |
Created |
Other Pages: Discs (No Data); DLG3 (No Data); KIAA1232 (No Data); Kiaa1232 (No Data); MRX (Redirect -> ABCG2); Mrx (Redirect -> ABCG2); MRX90 (No Data); Mrx90 (No Data); NE-Dlg (No Data); Ne-dlg (No Data); NEDLG (No Data); Nedlg (No Data); SAP102 (No Data); Sap102 (No Data); ABCG2 (Codes Found, but no match[skip]); |
[8] |
| DFFB |
Manual Inspection (Page not found) |
Other Pages: DNA fragmentation factor (No Data); DFFB (No Data); CAD (Redirect -> Computer-aided design); Cad (Redirect -> CAD (disambiguation)); CPAN (Unknown Data); Cpan (Redirect -> CPAN); DFF-40 (No Data); Dff-40 (No Data); DFF2 (No Data); Dff2 (No Data); DFF40 (No Data); Dff40 (No Data); Computer-aided design (Unknown Data); CAD (disambiguation) (DisAmbig); |
[9] |
| FANCG |
Manual Inspection (Page not found) |
Other Pages: Fanconi anemia (Unknown Data); FANCG (No Data); FAG (Redirect -> Fag); Fag (DisAmbig); XRCC9 (No Data); Xrcc9 (No Data); |
[10] |
| ADORA3 |
Created |
Other Pages: Adenosine A3 receptor (No Data); ADORA3 (No Data); A3AR (No Data); A3ar (No Data); AD026 (No Data); Ad026 (No Data); RP11-552M11.7 (No Data); Rp11-552m11.7 (No Data); BA552M11.5 (No Data); Ba552m11.5 (No Data); |
[11] |
| DHCR7 |
Manual Inspection (Page not found) |
Other Pages: 7-dehydrocholesterol reductase (Redirect -> 7-Dehydrocholesterol reductase); DHCR7 (Redirect -> 7-Dehydrocholesterol reductase); SLOS (No Data); Slos (No Data); 7-Dehydrocholesterol reductase (Protein Template); |
[12] |
| EXT2 |
Manual Inspection (Page not found) |
Other Pages: Exostoses 2 (No Data); EXT2 (Redirect -> Ext2); SOTV (No Data); Sotv (No Data); Ext2 (Unknown Data); |
[13] |
| ERG |
Manual Inspection (Page not found) |
Other Pages: V-ets erythroblastosis virus E26 oncogene homolog (No Data); ERG (Redirect -> Erg (disambiguation)); Erg-3 (No Data); P55 (Redirect -> CD120); Erg (disambiguation) (DisAmbig); CD120 (Codes Found, but no match[skip]); |
[14] |
| AKT3 |
Created |
Other Pages: V-akt murine thymoma viral oncogene homolog 3 (No Data); AKT3 (No Data); DKFZP434N0250 (No Data); Dkfzp434n0250 (No Data); PKBG (No Data); Pkbg (No Data); PRKBG (No Data); Prkbg (No Data); RAC-PK-gamma (No Data); Rac-pk-gamma (No Data); RAC-gamma (No Data); Rac-gamma (No Data); STK-2 (No Data); Stk-2 (No Data); |
[15] |
| E2F2 |
Created |
Other Pages: E2F transcription factor 2 (No Data); E2F2 (No Data); E2F-2 (No Data); E2f-2 (No Data); |
[16] |
| DNMT3A |
Created |
Other Pages: DNA -methyltransferase 3 alpha (No Data); DNMT3A (No Data); DNMT3A2 (No Data); Dnmt3a2 (No Data); M.HsaIIIA (No Data); M.hsaiiia (No Data); |
[17] |
| CHRNB2 |
Manual Inspection (Page not found) |
Other Pages: Cholinergic receptor (Redirect -> Acetylcholine receptor); CHRNB2 (No Data); EFNL3 (No Data); Efnl3 (No Data); NAChRB2 (No Data); Nachrb2 (No Data); Acetylcholine receptor (Unknown Data); |
[18] |
| CD69 |
Created |
Other Pages: CD69 molecule (No Data); CD69 (No Data); CLEC2C (No Data); Clec2c (No Data); |
[19] |
| RAPGEF3 |
Created |
Other Pages: Rap guanine nucleotide exchange factor 3 (No Data); RAPGEF3 (No Data); CAMP-GEFI (No Data); Camp-gefi (No Data); EPAC (No Data); Epac (No Data); EPAC1 (No Data); Epac1 (No Data); MGC21410 (No Data); Mgc21410 (No Data); Bcm910 (No Data); |
[20] |
| LTB4R |
Manual Inspection (Page not found) |
Other Pages: Leukotriene B4 receptor (Redirect -> Eicosanoid receptor); LTB4R (No Data); BLT1 (No Data); Blt1 (No Data); BLTR (No Data); Bltr (No Data); CMKRL1 (No Data); Cmkrl1 (No Data); GPR16 (No Data); Gpr16 (No Data); LTB4R1 (No Data); Ltb4r1 (No Data); LTBR1 (No Data); Ltbr1 (No Data); P2RY7 (No Data); P2ry7 (No Data); P2Y7 (No Data); P2y7 (No Data); Eicosanoid receptor (Unknown Data); |
[21] |
| GGA3 |
Created |
Other Pages: Golgi associated (No Data); GGA3 (No Data); KIAA0154 (No Data); Kiaa0154 (No Data); |
[22] |
| ETV4 |
Created |
Other Pages: Ets variant gene 4 (No Data); ETV4 (No Data); E1A-F (No Data); E1a-f (No Data); E1AF (No Data); E1af (No Data); PEA3 (No Data); Pea3 (No Data); PEAS3 (No Data); Peas3 (No Data); |
[23] |
| ARX |
Manual Inspection (Page not found) |
Other Pages: Aristaless related homeobox (Protein Template); ARX (Redirect -> Arx); ISSX (No Data); Issx (No Data); MRX29 (No Data); Mrx29 (No Data); MRX32 (No Data); Mrx32 (No Data); MRX33 (No Data); Mrx33 (No Data); MRX36 (No Data); Mrx36 (No Data); MRX38 (No Data); Mrx38 (No Data); MRX43 (No Data); Mrx43 (No Data); MRX54 (No Data); Mrx54 (No Data); MRXS1 (No Data); Mrxs1 (No Data); PRTS (No Data); Prts (No Data); Arx (DisAmbig); |
[24] |
| ABI1 |
Created |
Other Pages: Abl-interactor 1 (No Data); ABI1 (No Data); ABI-1 (No Data); Abi-1 (No Data); E3B1 (No Data); E3b1 (No Data); NAP1BP (No Data); Nap1bp (No Data); SSH3BP (No Data); Ssh3bp (No Data); SSH3BP1 (No Data); Ssh3bp1 (No Data); |
[25] |
[edit] Vebose Log - Date: 05:00, 10 November 2007 (UTC)
- INFO: Beginning work on ABI1... {November 9, 2007 8:46:46 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:47:52 PM PST}
- CREATED: Created new protein page: ABI1 {November 9, 2007 8:48:00 PM PST}
- INFO: Beginning work on ADORA3... {November 9, 2007 8:26:17 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:27:01 PM PST}
- CREATED: Created new protein page: ADORA3 {November 9, 2007 8:27:09 PM PST}
- INFO: Beginning work on AKT3... {November 9, 2007 8:45:09 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:46:39 PM PST}
- CREATED: Created new protein page: AKT3 {November 9, 2007 8:46:46 PM PST}
- INFO: Beginning work on ARX... {November 9, 2007 8:51:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:52:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Aristaless related homeobox
| HGNCid = 18060
| Symbol = ARX
| AltSymbols =; ISSX; MRX29; MRX32; MRX33; MRX36; MRX38; MRX43; MRX54; MRXS1; PRTS
| OMIM = 300382
| ECnumber =
| Homologene = 68998
| MGIid = 1097716
| GeneAtlas_image1 = PBB_GE_ARX_gnf1h01283_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARX_gnf1h01284_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 170302
| Hs_Ensembl = ENSG00000004848
| Hs_RefseqProtein = NP_620689
| Hs_RefseqmRNA = NM_139058
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 24931732
| Hs_GenLoc_end = 24943986
| Hs_Uniprot = Q96QS3
| Mm_EntrezGene = 11878
| Mm_Ensembl = ENSMUSG00000035277
| Mm_RefseqmRNA = XM_979717
| Mm_RefseqProtein = XP_984811
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 89539365
| Mm_GenLoc_end = 89551080
| Mm_Uniprot = O35085
}}
}}
'''Aristaless related homeobox''', also known as '''ARX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Mutations in this gene cause X-linked mental retardation and epilepsy.<ref>{{cite web | title = Entrez Gene: ARX aristaless related homeobox| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=170302| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mulley JC, Kerr B, Stevenson R, Lubs H |title=Nomenclature guidelines for X-linked mental retardation. |journal=Am. J. Med. Genet. |volume=43 |issue= 1-2 |pages= 383-91 |year= 1992 |pmid= 1605216 |doi= }}
*{{cite journal | author=Häne B, Schroer RJ, Arena JF, ''et al.'' |title=Nonsyndromic X-linked mental retardation: review and mapping of MRX29 to Xp21. |journal=Clin. Genet. |volume=50 |issue= 4 |pages= 176-83 |year= 1997 |pmid= 9001795 |doi= }}
*{{cite journal | author=Suri M |title=The phenotypic spectrum of ARX mutations. |journal=Developmental medicine and child neurology |volume=47 |issue= 2 |pages= 133-7 |year= 2005 |pmid= 15707237 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD69... {November 9, 2007 8:27:09 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 8:27:53 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:28:03 PM PST}
- CREATED: Created new protein page: CD69 {November 9, 2007 8:28:10 PM PST}
- INFO: Beginning work on CHRNB2... {November 9, 2007 8:28:44 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:29:32 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, nicotinic, beta 2 (neuronal)
| HGNCid = 1962
| Symbol = CHRNB2
| AltSymbols =; EFNL3; nAChRB2
| OMIM = 118507
| ECnumber =
| Homologene = 595
| MGIid = 87891
| GeneAtlas_image1 = PBB_GE_CHRNB2_206635_at_tn.png
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}}
| Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007600 |text = sensory perception}} {{GNF_GO|id=GO:0007613 |text = memory}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1141
| Hs_Ensembl = ENSG00000160716
| Hs_RefseqProtein = NP_000739
| Hs_RefseqmRNA = NM_000748
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 152806881
| Hs_GenLoc_end = 152819126
| Hs_Uniprot = P17787
| Mm_EntrezGene = 11444
| Mm_Ensembl = ENSMUSG00000027950
| Mm_RefseqmRNA = NM_009602
| Mm_RefseqProtein = NP_033732
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 89839375
| Mm_GenLoc_end = 89850512
| Mm_Uniprot = Q61943
}}
}}
'''Cholinergic receptor, nicotinic, beta 2 (neuronal)''', also known as '''CHRNB2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.<ref>{{cite web | title = Entrez Gene: CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1141| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Skorupska E, Rózycka A, Trzeciak WH |title=[Molecular and genetic basis of idiopathic nocturnal frontal lobe epilepsy] |journal=Neurol. Neurochir. Pol. |volume=36 |issue= 3 |pages= 513-25 |year= 2002 |pmid= 12185808 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL5A1... {November 9, 2007 8:30:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:31:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type V, alpha 1
| HGNCid = 2209
| Symbol = COL5A1
| AltSymbols =;
| OMIM = 120215
| ECnumber =
| Homologene = 55434
| MGIid = 88457
| GeneAtlas_image1 = PBB_GE_COL5A1_203325_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL5A1_212488_at_tn.png
| GeneAtlas_image3 = PBB_GE_COL5A1_212489_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005588 |text = collagen type V}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1289
| Hs_Ensembl = ENSG00000130635
| Hs_RefseqProtein = NP_000084
| Hs_RefseqmRNA = NM_000093
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 136673473
| Hs_GenLoc_end = 136876507
| Hs_Uniprot = P20908
| Mm_EntrezGene = 12831
| Mm_Ensembl = ENSMUSG00000026837
| Mm_RefseqmRNA = NM_015734
| Mm_RefseqProtein = NP_056549
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 27708694
| Mm_GenLoc_end = 27861166
| Mm_Uniprot = Q6F6B0
}}
}}
'''Collagen, type V, alpha 1''', also known as '''COL5A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.<ref>{{cite web | title = Entrez Gene: COL5A1 collagen, type V, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1289| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP11B1... {November 9, 2007 8:31:31 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:32:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 11, subfamily B, polypeptide 1
| HGNCid = 2591
| Symbol = CYP11B1
| AltSymbols =; CPN1; CYP11B; DKFZp686B05283; FHI; FLJ36771; P450C11
| OMIM = 610613
| ECnumber =
| Homologene = 88331
| MGIid = 88584
| GeneAtlas_image1 = PBB_GE_CYP11B1_214610_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0004507 |text = steroid 11-beta-monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006700 |text = C21-steroid hormone biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1584
| Hs_Ensembl = ENSG00000160882
| Hs_RefseqProtein = NP_000488
| Hs_RefseqmRNA = NM_000497
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 143950780
| Hs_GenLoc_end = 143958238
| Hs_Uniprot = P15538
| Mm_EntrezGene = 13072
| Mm_Ensembl = ENSMUSG00000022589
| Mm_RefseqmRNA = NM_009991
| Mm_RefseqProtein = NP_034121
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 74678294
| Mm_GenLoc_end = 74683480
| Mm_Uniprot = Q14AB5
}}
}}
'''Cytochrome P450, family 11, subfamily B, polypeptide 1''', also known as '''CYP11B1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.<ref>{{cite web | title = Entrez Gene: CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1584| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Helmberg A |title=Twin genes and endocrine disease: CYP21 and CYP11B genes. |journal=Acta Endocrinol. |volume=129 |issue= 2 |pages= 97-108 |year= 1993 |pmid= 8372604 |doi= }}
*{{cite journal | author=Stowasser M, Gunasekera TG, Gordon RD |title=Familial varieties of primary aldosteronism. |journal=Clin. Exp. Pharmacol. Physiol. |volume=28 |issue= 12 |pages= 1087-90 |year= 2002 |pmid= 11903322 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DDB2... {November 9, 2007 8:32:21 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:32:57 PM PST}
- CREATED: Created new protein page: DDB2 {November 9, 2007 8:33:05 PM PST}
- INFO: Beginning work on DFFB... {November 9, 2007 8:33:05 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 8:33:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:34:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DFFB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ibx.
| PDB = {{PDB2|1ibx}}
| Name = DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
| HGNCid = 2773
| Symbol = DFFB
| AltSymbols =; CAD; CPAN; DFF-40; DFF2; DFF40
| OMIM = 601883
| ECnumber =
| Homologene = 3241
| MGIid = 1196287
| GeneAtlas_image1 = PBB_GE_DFFB_206752_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004516 |text = nicotinate phosphoribosyltransferase activity}} {{GNF_GO|id=GO:0004518 |text = nuclease activity}} {{GNF_GO|id=GO:0004537 |text = caspase-activated deoxyribonuclease activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0030263 |text = apoptotic chromosome condensation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1677
| Hs_Ensembl = ENSG00000169598
| Hs_RefseqProtein = NP_001004285
| Hs_RefseqmRNA = NM_001004285
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 3763705
| Hs_GenLoc_end = 3791853
| Hs_Uniprot = O76075
| Mm_EntrezGene = 13368
| Mm_Ensembl = ENSMUSG00000029027
| Mm_RefseqmRNA = NM_007859
| Mm_RefseqProtein = NP_031885
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 152808255
| Mm_GenLoc_end = 152818926
| Mm_Uniprot = Q7TS81
}}
}}
'''DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)''', also known as '''DFFB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.<ref>{{cite web | title = Entrez Gene: DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1677| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DHCR7... {November 9, 2007 8:34:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:35:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 7-dehydrocholesterol reductase
| HGNCid = 2860
| Symbol = DHCR7
| AltSymbols =; SLOS
| OMIM = 602858
| ECnumber =
| Homologene = 1042
| MGIid = 1298378
| GeneAtlas_image1 = PBB_GE_DHCR7_201791_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DHCR7_201790_s_at_tn.png
| Function = {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0047598 |text = 7-dehydrocholesterol reductase activity}}
| Component = {{GNF_GO|id=GO:0005640 |text = nuclear outer membrane}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001568 |text = blood vessel development}} {{GNF_GO|id=GO:0006695 |text = cholesterol biosynthetic process}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1717
| Hs_Ensembl = ENSG00000172893
| Hs_RefseqProtein = NP_001351
| Hs_RefseqmRNA = NM_001360
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 70823111
| Hs_GenLoc_end = 70837050
| Hs_Uniprot = Q9UBM7
| Mm_EntrezGene = 13360
| Mm_Ensembl = ENSMUSG00000058454
| Mm_RefseqmRNA = XM_001002212
| Mm_RefseqProtein = XP_001002212
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 143632557
| Mm_GenLoc_end = 143657800
| Mm_Uniprot = Q3UIQ5
}}
}}
'''7-dehydrocholesterol reductase''', also known as '''DHCR7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Waterham HR, Wanders RJ |title=Biochemical and genetic aspects of 7-dehydrocholesterol reductase and Smith-Lemli-Opitz syndrome. |journal=Biochim. Biophys. Acta |volume=1529 |issue= 1-3 |pages= 340-56 |year= 2001 |pmid= 11111101 |doi= }}
*{{cite journal | author=Nowaczyk MJ, Nakamura LM, Waye JS |title=DHCR7 and Smith-Lemli-Opitz syndrome. |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=24 |issue= 6 |pages= 311-7 |year= 2002 |pmid= 11767235 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DLG3... {November 9, 2007 8:35:15 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 8:37:00 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:37:25 PM PST}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=DLG3>DLG3</a> {November 9, 2007 8:37:34 PM PST}
- CREATED: Created new protein page: DLG3 {November 9, 2007 8:37:46 PM PST}
- INFO: Beginning work on DNMT3A... {November 9, 2007 8:37:46 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:38:30 PM PST}
- CREATED: Created new protein page: DNMT3A {November 9, 2007 8:38:38 PM PST}
- INFO: Beginning work on DSG3... {November 9, 2007 8:38:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:39:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Desmoglein 3 (pemphigus vulgaris antigen)
| HGNCid = 3050
| Symbol = DSG3
| AltSymbols =; CDHF6; DKFZp686P23184; PVA
| OMIM = 169615
| ECnumber =
| Homologene = 55513
| MGIid = 99499
| GeneAtlas_image1 = PBB_GE_DSG3_205595_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1830
| Hs_Ensembl = ENSG00000134757
| Hs_RefseqProtein = NP_001935
| Hs_RefseqmRNA = NM_001944
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 27281756
| Hs_GenLoc_end = 27310474
| Hs_Uniprot = P32926
| Mm_EntrezGene = 13512
| Mm_Ensembl = ENSMUSG00000056632
| Mm_RefseqmRNA = XM_984295
| Mm_RefseqProtein = XP_989389
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 20653284
| Mm_GenLoc_end = 20683759
| Mm_Uniprot = Q3UFC6
}}
}}
'''Desmoglein 3 (pemphigus vulgaris antigen)''', also known as '''DSG3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.<ref>{{cite web | title = Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1830| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on E2F2... {November 9, 2007 8:39:22 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:39:41 PM PST}
- CREATED: Created new protein page: E2F2 {November 9, 2007 8:39:48 PM PST}
- INFO: Beginning work on ERG... {November 9, 2007 8:39:48 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 8:41:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:41:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ERG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fli.
| PDB = {{PDB2|1fli}}, {{PDB2|1sxe}}
| Name = V-ets erythroblastosis virus E26 oncogene homolog (avian)
| HGNCid = 3446
| Symbol = ERG
| AltSymbols =; erg-3; p55
| OMIM = 165080
| ECnumber =
| Homologene = 15848
| MGIid = 95415
| GeneAtlas_image1 = PBB_GE_ERG_211626_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_ERG_213541_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ERG_222079_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2078
| Hs_Ensembl = ENSG00000157554
| Hs_RefseqProtein = NP_004440
| Hs_RefseqmRNA = NM_004449
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 38675671
| Hs_GenLoc_end = 38955488
| Hs_Uniprot = P11308
| Mm_EntrezGene = 13876
| Mm_Ensembl = ENSMUSG00000040732
| Mm_RefseqmRNA = XM_001004957
| Mm_RefseqProtein = XP_001004957
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 95469604
| Mm_GenLoc_end = 95518756
| Mm_Uniprot = Q3UQJ4
}}
}}
'''V-ets erythroblastosis virus E26 oncogene homolog (avian)''', also known as '''ERG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ETV4... {November 9, 2007 8:41:22 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:42:09 PM PST}
- CREATED: Created new protein page: ETV4 {November 9, 2007 8:42:17 PM PST}
- INFO: Beginning work on EXT2... {November 9, 2007 8:42:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:43:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Exostoses (multiple) 2
| HGNCid = 3513
| Symbol = EXT2
| AltSymbols =; SOTV
| OMIM = 608210
| ECnumber =
| Homologene = 345
| MGIid = 108050
| GeneAtlas_image1 = PBB_GE_EXT2_202012_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EXT2_202013_s_at_tn.png
| Function = {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0050508 |text = glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity}} {{GNF_GO|id=GO:0050509 |text = N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006024 |text = glycosaminoglycan biosynthetic process}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2132
| Hs_Ensembl = ENSG00000151348
| Hs_RefseqProtein = NP_000392
| Hs_RefseqmRNA = NM_000401
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 44073675
| Hs_GenLoc_end = 44223555
| Hs_Uniprot = Q93063
| Mm_EntrezGene = 14043
| Mm_Ensembl = ENSMUSG00000027198
| Mm_RefseqmRNA = NM_010163
| Mm_RefseqProtein = NP_034293
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 93496472
| Mm_GenLoc_end = 93623384
| Mm_Uniprot = Q3TPI7
}}
}}
'''Exostoses (multiple) 2''', also known as '''EXT2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses.<ref>{{cite web | title = Entrez Gene: EXT2 exostoses (multiple) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2132| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wuyts W, Van Hul W |title=Molecular basis of multiple exostoses: mutations in the EXT1 and EXT2 genes. |journal=Hum. Mutat. |volume=15 |issue= 3 |pages= 220-7 |year= 2000 |pmid= 10679937 |doi= 10.1002/(SICI)1098-1004(200003)15:3<220::AID-HUMU2>3.0.CO;2-K }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FANCG... {November 9, 2007 8:43:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:45:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Fanconi anemia, complementation group G
| HGNCid = 3588
| Symbol = FANCG
| AltSymbols =; FAG; XRCC9
| OMIM = 602956
| ECnumber =
| Homologene = 3402
| MGIid = 1926471
| GeneAtlas_image1 = PBB_GE_FANCG_203564_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0001541 |text = ovarian follicle development}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0007286 |text = spermatid development}} {{GNF_GO|id=GO:0009314 |text = response to radiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2189
| Hs_Ensembl = ENSG00000165281
| Hs_RefseqProtein = NP_004620
| Hs_RefseqmRNA = NM_004629
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 35063835
| Hs_GenLoc_end = 35070013
| Hs_Uniprot = O15287
| Mm_EntrezGene = 60534
| Mm_Ensembl = ENSMUSG00000028453
| Mm_RefseqmRNA = NM_053081
| Mm_RefseqProtein = NP_444311
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 43023444
| Mm_GenLoc_end = 43031588
| Mm_Uniprot = Q8VHS1
}}
}}
'''Fanconi anemia, complementation group G''', also known as '''FANCG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = FANCG, involved in Fanconi anemia, confers resistance to both hygromycin and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino acid protein has a leucine-zipper motif at its N-terminus. Fanconi anemia is an autosomal recessive disorder with diverse clinical symptoms, including developmental anomalies, bone marrow failure, and early occurrence of malignancies. A minimum of 8 FA genes have been identified. The FANCG gene is responsible for complementation group G.<ref>{{cite web | title = Entrez Gene: FANCG Fanconi anemia, complementation group G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2189| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FST... {November 9, 2007 8:48:50 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 8:49:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:49:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FST_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lr7.
| PDB = {{PDB2|1lr7}}, {{PDB2|1lr8}}, {{PDB2|1lr9}}, {{PDB2|2arp}}, {{PDB2|2b0u}}, {{PDB2|2p6a}}
| Name = Follistatin
| HGNCid = 3971
| Symbol = FST
| AltSymbols =; FS
| OMIM = 136470
| ECnumber =
| Homologene = 7324
| MGIid = 95586
| GeneAtlas_image1 = PBB_GE_FST_204948_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017106 |text = activin inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007276 |text = gamete generation}} {{GNF_GO|id=GO:0007389 |text = pattern specification process}} {{GNF_GO|id=GO:0008585 |text = female gonad development}} {{GNF_GO|id=GO:0030509 |text = BMP signaling pathway}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0046882 |text = negative regulation of follicle-stimulating hormone secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10468
| Hs_Ensembl = ENSG00000134363
| Hs_RefseqProtein = NP_006341
| Hs_RefseqmRNA = NM_006350
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 52812174
| Hs_GenLoc_end = 52817659
| Hs_Uniprot = P19883
| Mm_EntrezGene = 14313
| Mm_Ensembl = ENSMUSG00000021765
| Mm_RefseqmRNA = NM_008046
| Mm_RefseqProtein = NP_032072
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 115574301
| Mm_GenLoc_end = 115579608
| Mm_Uniprot = Q8BNY0
}}
}}
'''Follistatin''', also known as '''FST''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.<ref>{{cite web | title = Entrez Gene: FST follistatin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10468| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Peng C, Ohno T, Khorasheh S, Leung PC |title=Activin and follistatin as local regulators in the human ovary. |journal=Biol. Signals |volume=5 |issue= 2 |pages= 81-9 |year= 1996 |pmid= 8836491 |doi= }}
*{{cite journal | author=Phillips DJ, de Kretser DM |title=Follistatin: a multifunctional regulatory protein. |journal=Frontiers in neuroendocrinology |volume=19 |issue= 4 |pages= 287-322 |year= 1998 |pmid= 9799587 |doi= 10.1006/frne.1998.0169 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GGA3... {November 9, 2007 8:49:39 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 8:50:27 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:50:37 PM PST}
- CREATED: Created new protein page: GGA3 {November 9, 2007 8:50:45 PM PST}
- INFO: Beginning work on LTB4R... {November 9, 2007 8:29:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:30:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Leukotriene B4 receptor
| HGNCid = 6713
| Symbol = LTB4R
| AltSymbols =; BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7
| OMIM = 601531
| ECnumber =
| Homologene = 22477
| MGIid = 1309472
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004974 |text = leukotriene receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1241
| Hs_Ensembl =
| Hs_RefseqProtein = NP_858043
| Hs_RefseqmRNA = NM_181657
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16995
| Mm_Ensembl = ENSMUSG00000046908
| Mm_RefseqmRNA = NM_008519
| Mm_RefseqProtein = NP_032545
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 54720038
| Mm_GenLoc_end = 54722563
| Mm_Uniprot = Q3U2P2
}}
}}
'''Leukotriene B4 receptor''', also known as '''LTB4R''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Raport CJ, Schweickart VL, Chantry D, ''et al.'' |title=New members of the chemokine receptor gene family. |journal=J. Leukoc. Biol. |volume=59 |issue= 1 |pages= 18-23 |year= 1996 |pmid= 8558062 |doi= }}
*{{cite journal | author=Tager AM, Luster AD |title=BLT1 and BLT2: the leukotriene B(4) receptors. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=69 |issue= 2-3 |pages= 123-34 |year= 2004 |pmid= 12895595 |doi= }}
*{{cite journal | author=Miyahara N, Miyahara S, Takeda K, Gelfand EW |title=Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation. |journal=Allergology international : official journal of the Japanese Society of Allergology |volume=55 |issue= 2 |pages= 91-7 |year= 2006 |pmid= 17075244 |doi= 10.2332/allergolint.55.91 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAPGEF3... {November 9, 2007 8:48:00 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:48:40 PM PST}
- CREATED: Created new protein page: RAPGEF3 {November 9, 2007 8:48:50 PM PST}
- INFO: Beginning work on RCC1... {November 9, 2007 8:28:10 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 8:28:25 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:28:37 PM PST}
- CREATED: Created new protein page: RCC1 {November 9, 2007 8:28:44 PM PST}
- INFO: Beginning work on TPH2... {November 9, 2007 8:50:45 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:51:09 PM PST}
- CREATED: Created new protein page: TPH2 {November 9, 2007 8:51:17 PM PST}
end log.
