DLG3

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Discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
PDB rendering based on 1um7.
Available structures: 1um7, 2fe5, 2i1n
Identifiers
Symbol(s) DLG3; KIAA1232; MRX; MRX90; NE-Dlg; NEDLG; SAP102
External IDs OMIM: 300189 MGI: 1888986 HomoloGene: 41157
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1741 53310
Ensembl ENSG00000082458 ENSMUSG00000000881
Uniprot Q92796 Q80TH1
Refseq NM_020730 (mRNA)
NP_065781 (protein)		 NM_016747 (mRNA)
NP_058027 (protein)
Location Chr X: 69.58 - 69.64 Mb Chr X: 96.97 - 97.02 Mb
Pubmed search [1] [2]

Discs, large homolog 3 (neuroendocrine-dlg, Drosophila), also known as DLG3, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: DLG3 Discs, large homolog 3 (neuroendocrine-dlg, Drosophila).

[edit] Further reading

  • Lau LF, Mammen A, Ehlers MD, et al. (1996). "Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102.". J. Biol. Chem. 271 (35): 21622–8. PMID 8702950. 
  • Müller BM, Kistner U, Kindler S, et al. (1996). "SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo.". Neuron 17 (2): 255–65. PMID 8780649. 
  • Takeuchi M, Hata Y, Hirao K, et al. (1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.". J. Biol. Chem. 272 (18): 11943–51. PMID 9115257. 
  • Makino K, Kuwahara H, Masuko N, et al. (1997). "Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.". Oncogene 14 (20): 2425–33. doi:10.1038/sj.onc.1201087. PMID 9188857. 
  • Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95.". Science 277 (5331): 1511–5. PMID 9278515. 
  • Kim JH, Liao D, Lau LF, Huganir RL (1998). "SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.". Neuron 20 (4): 683–91. PMID 9581761. 
  • Stathakis DG, Lee D, Bryant PJ (1998). "DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1.". Genomics 49 (2): 310–3. doi:10.1006/geno.1998.5243. PMID 9598320. 
  • Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.". Cell 94 (6): 773–82. PMID 9753324. 
  • Garcia EP, Mehta S, Blair LA, et al. (1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization.". Neuron 21 (4): 727–39. PMID 9808460. 
  • Masuko N, Makino K, Kuwahara H, et al. (1999). "Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites.". J. Biol. Chem. 274 (9): 5782–90. PMID 10026200. 
  • Kuwahara H, Araki N, Makino K, et al. (1999). "A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor.". J. Biol. Chem. 274 (45): 32204–14. PMID 10542258. 
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. PMID 10574462. 
  • Firestein BL, Firestein BL, Brenman JE, et al. (2000). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting.". Neuron 24 (3): 659–72. PMID 10595517. 
  • Garcia RA, Vasudevan K, Buonanno A (2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3596–601. doi:10.1073/pnas.070042497. PMID 10725395. 
  • Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698. 
  • Inagaki S, Ohoka Y, Sugimoto H, et al. (2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026. 
  • DeMarco SJ, Strehler EE (2001). "Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.". J. Biol. Chem. 276 (24): 21594–600. doi:10.1074/jbc.M101448200. PMID 11274188. 
  • Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861. 
  • Lim IA, Hall DD, Hell JW (2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501. 
  • Cai C, Coleman SK, Niemi K, Keinänen K (2002). "Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.". J. Biol. Chem. 277 (35): 31484–90. doi:10.1074/jbc.M204354200. PMID 12070168. 
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