DNMT3A

From Wikipedia, the free encyclopedia

DNA (cytosine-5-)-methyltransferase 3 alpha

Identifiers

DNMT3A; DNMT3A2; M.HsaIIIA

External IDs

OMIM: 602769 MGI: 1261827 HomoloGene: 7294

Gene ontology
Molecular Function:	• DNA binding • DNA (cytosine-5-)-methyltransferase activity • protein binding • methyltransferase activity • zinc ion binding • transferase activity • metal ion binding
Cellular Component:	• euchromatin • nucleus • cytoplasm • nuclear matrix
Biological Process:	• DNA methylation • imprinting

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022552 (mRNA)
NP_072046 (protein)

NM_007872 (mRNA)
NP_031898 (protein)

Location

Chr 2: 25.31 - 25.42 Mb

Chr 12: 3.81 - 3.91 Mb

Pubmed search

[1]

[2]

DNA (cytosine-5-)-methyltransferase 3 alpha, also known as DNMT3A, is a human gene.

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ Entrez Gene: DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha.

[edit] Further reading

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Okano M, Xie S, Li E (1998). "Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases.". Nat. Genet. 19 (3): 219–20. doi:10.1038/890. PMID 9662389.
Robertson KD, Uzvolgyi E, Liang G, et al. (1999). "The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.". Nucleic Acids Res. 27 (11): 2291–8. PMID 10325416.
Xie S, Wang Z, Okano M, et al. (1999). "Cloning, expression and chromosome locations of the human DNMT3 gene family.". Gene 236 (1): 87–95. PMID 10433969.
Fuks F, Burgers WA, Godin N, et al. (2001). "Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription.". EMBO J. 20 (10): 2536–44. doi:10.1093/emboj/20.10.2536. PMID 11350943.
Vaute O, Nicolas E, Vandel L, Trouche D (2002). "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases.". Nucleic Acids Res. 30 (2): 475–81. PMID 11788710.
Di Croce L, Raker VA, Corsaro M, et al. (2002). "Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.". Science 295 (5557): 1079–82. doi:10.1126/science.1065173. PMID 11834837.
Hata K, Okano M, Lei H, Li E (2002). "Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice.". Development 129 (8): 1983–93. PMID 11934864.
Chen T, Ueda Y, Xie S, Li E (2002). "A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.". J. Biol. Chem. 277 (41): 38746–54. doi:10.1074/jbc.M205312200. PMID 12138111.
Kim GD, Ni J, Kelesoglu N, et al. (2002). "Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.". EMBO J. 21 (15): 4183–95. PMID 12145218.
Yanagisawa Y, Ito E, Yuasa Y, Maruyama K (2002). "The human DNA methyltransferases DNMT3A and DNMT3B have two types of promoters with different CpG contents.". Biochim. Biophys. Acta 1577 (3): 457–65. PMID 12359337.
Fatemi M, Hermann A, Gowher H, Jeltsch A (2002). "Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA.". Eur. J. Biochem. 269 (20): 4981–4. PMID 12383256.
Weisenberger DJ, Velicescu M, Preciado-Lopez MA, et al. (2003). "Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells.". Gene 298 (1): 91–9. PMID 12406579.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chedin F, Lieber MR, Hsieh CL (2003). "The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16916–21. doi:10.1073/pnas.262443999. PMID 12481029.
Robert MF, Morin S, Beaulieu N, et al. (2003). "DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.". Nat. Genet. 33 (1): 61–5. doi:10.1038/ng1068. PMID 12496760.
Fuks F, Hurd PJ, Deplus R, Kouzarides T (2003). "The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase.". Nucleic Acids Res. 31 (9): 2305–12. PMID 12711675.
Yakushiji T, Uzawa K, Shibahara T, et al. (2003). "Over-expression of DNA methyltransferases and CDKN2A gene methylation status in squamous cell carcinoma of the oral cavity.". Int. J. Oncol. 22 (6): 1201–7. PMID 12738984.
Ling Y, Sankpal UT, Robertson AK, et al. (2004). "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription.". Nucleic Acids Res. 32 (2): 598–610. doi:10.1093/nar/gkh195. PMID 14752048.