TPH2

From Wikipedia, the free encyclopedia

Tryptophan hydroxylase 2

Identifiers

Symbol(s)

TPH2; FLJ37295; MGC138871; MGC138872; NTPH

External IDs

OMIM: 607478 MGI: 2651811 HomoloGene: 27831

EC number

1.14.16.4

Gene ontology
Molecular Function:	• monooxygenase activity • tryptophan 5-monooxygenase activity • iron ion binding • amino acid binding • metal ion binding
Biological Process:	• serotonin biosynthetic process from tryptophan • metabolic process • aromatic amino acid family metabolic process • serotonin biosynthetic process

Orthologs

Human

Mouse

Refseq

NM_173353 (mRNA)
NP_775489 (protein)

NM_173391 (mRNA)
NP_775567 (protein)

Location

Chr 12: 70.62 - 70.71 Mb

Chr 10: 114.48 - 114.59 Mb

Pubmed search

[1]

[2]

Tryptophan hydroxylase 2, also known as TPH2, is a human gene.

Tryptophan hydroxylase (TPH; EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility.[supplied by OMIM]^[1]

[edit] See also

Tryptophan hydroxylase

[edit] References

^ Entrez Gene: TPH2 tryptophan hydroxylase 2.

[edit] Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Walther DJ, Peter JU, Bashammakh S, et al. (2003). "Synthesis of serotonin by a second tryptophan hydroxylase isoform.". Science 299 (5603): 76. doi:10.1126/science.1078197. PMID 12511643.
Walther DJ, Bader M (2003). "A unique central tryptophan hydroxylase isoform.". Biochem. Pharmacol. 66 (9): 1673-80. PMID 14563478.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Zill P, Baghai TC, Zwanzger P, et al. (2005). "SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression.". Mol. Psychiatry 9 (11): 1030-6. doi:10.1038/sj.mp.4001525. PMID 15124006.
Breidenthal SE, White DJ, Glatt CE (2005). "Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2).". Psychiatr. Genet. 14 (2): 69-72. PMID 15167691.
De Luca V, Mueller DJ, Tharmalingam S, et al. (2005). "Analysis of the novel TPH2 gene in bipolar disorder and suicidality.". Mol. Psychiatry 9 (10): 896-7. doi:10.1038/sj.mp.4001531. PMID 15197398.
Harvey M, Shink E, Tremblay M, et al. (2005). "Support for the involvement of TPH2 gene in affective disorders.". Mol. Psychiatry 9 (11): 980-1. doi:10.1038/sj.mp.4001557. PMID 15263906.
Zill P, Büttner A, Eisenmenger W, et al. (2005). "Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims.". Biol. Psychiatry 56 (8): 581-6. doi:10.1016/j.biopsych.2004.07.015. PMID 15476687.
Zhang X, Gainetdinov RR, Beaulieu JM, et al. (2005). "Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.". Neuron 45 (1): 11-6. doi:10.1016/j.neuron.2004.12.014. PMID 15629698.
Coon H, Dunn D, Lainhart J, et al. (2005). "Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2).". Am. J. Med. Genet. B Neuropsychiatr. Genet. 135 (1): 42-6. doi:10.1002/ajmg.b.30168. PMID 15768392.
Sheehan K, Lowe N, Kirley A, et al. (2005). "Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.". Mol. Psychiatry 10 (10): 944-9. doi:10.1038/sj.mp.4001698. PMID 15940290.
Shamir A, Shaltiel G, Levi I, et al. (2005). "Postmortem parietal cortex TPH2 expression is not altered in schizophrenic, unipolar-depressed, and bipolar patients vs control subjects.". J. Mol. Neurosci. 26 (1): 33-7. PMID 15968084.
Brown SM, Peet E, Manuck SB, et al. (2005). "A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity.". Mol. Psychiatry 10 (9): 884-8, 805. doi:10.1038/sj.mp.4001716. PMID 16044172.
Walitza S, Renner TJ, Dempfle A, et al. (2006). "Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.". Mol. Psychiatry 10 (12): 1126-32. doi:10.1038/sj.mp.4001734. PMID 16116490.
Canli T, Congdon E, Gutknecht L, et al. (2006). "Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation.". Journal of neural transmission (Vienna, Austria : 1996) 112 (11): 1479-85. doi:10.1007/s00702-005-0391-4. PMID 16245070.
Mössner R, Freitag CM, Gutknecht L, et al. (2006). "The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder.". J. Psychopharmacol. (Oxford) 20 (4): 547-52. doi:10.1177/0269881106059704. PMID 16401665.
De Luca V, Hlousek D, Likhodi O, et al. (2006). "The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses.". Genes Brain Behav. 5 (1): 107-10. doi:10.1111/j.1601-183X.2005.00182.x. PMID 16436194.
Delorme R, Durand CM, Betancur C, et al. (2006). "No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects.". Biol. Psychiatry 60 (2): 202-3. doi:10.1016/j.biopsych.2005.12.014. PMID 16581035.
Carkaci-Salli N, Flanagan JM, Martz MK, et al. (2006). "Functional domains of human tryptophan hydroxylase 2 (hTPH2).". J. Biol. Chem. 281 (38): 28105-12. doi:10.1074/jbc.M602817200. PMID 16864580.