Hot 100 number-one hits of 2005 (United States)
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This is a list of the U.S. Billboard magazine Hot 100 number-ones of 2005.
| Issue Date | Song | Artist |
| January 1 | "Let Me Love You" | Mario |
| January 8 | "Let Me Love You" | Mario |
| January 15 | "Let Me Love You" | Mario |
| January 22 | "Let Me Love You" | Mario |
| January 29 | "Let Me Love You" | Mario |
| February 5 | "Let Me Love You" | Mario |
| February 12 | "Let Me Love You" | Mario |
| February 19 | "Let Me Love You" | Mario |
| February 26 | "Let Me Love You" | Mario |
| March 5 | "Candy Shop" | 50 Cent featuring Olivia |
| March 12 | "Candy Shop" | 50 Cent featuring Olivia |
| March 19 | "Candy Shop" | 50 Cent featuring Olivia |
| March 26 | "Candy Shop" | 50 Cent featuring Olivia |
| April 2 | "Candy Shop" | 50 Cent featuring Olivia |
| April 9 | "Candy Shop" | 50 Cent featuring Olivia |
| April 16 | "Candy Shop" | 50 Cent featuring Olivia |
| April 23 | "Candy Shop" | 50 Cent featuring Olivia |
| April 30 | "Candy Shop" | 50 Cent featuring Olivia |
| May 7 | "Hollaback Girl" | Gwen Stefani |
| May 14 | "Hollaback Girl" | Gwen Stefani |
| May 21 | "Hollaback Girl" | Gwen Stefani |
| May 28 | "Hollaback Girl" | Gwen Stefani |
| June 4 | "We Belong Together" | Mariah Carey |
| June 11 | "We Belong Together" | Mariah Carey |
| June 18 | "We Belong Together" | Mariah Carey |
| June 25 | "We Belong Together" | Mariah Carey |
| July 2 | "Inside Your Heaven" | Carrie Underwood |
| July 9 | "We Belong Together" | Mariah Carey |
| July 16 | "We Belong Together" | Mariah Carey |
| July 23 | "We Belong Together" | Mariah Carey |
| July 30 | "We Belong Together" | Mariah Carey |
| August 6 | "We Belong Together" | Mariah Carey |
| August 13 | "We Belong Together" | Mariah Carey |
| August 20 | "We Belong Together" | Mariah Carey |
| August 27 | "We Belong Together" | Mariah Carey |
| September 3 | "We Belong Together" | Mariah Carey |
| September 10 | "We Belong Together" | Mariah Carey |
| September 17 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| September 24 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| October 1 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| October 8 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| October 15 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| October 22 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| October 29 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| November 5 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| November 12 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| November 19 | "Gold Digger" | Kanye West featuring Jamie Foxx |
| November 26 | "Run It!" | Chris Brown |
| December 3 | "Run It!" | Chris Brown |
| December 10 | "Run It!" | Chris Brown |
| December 17 | "Run It!" | Chris Brown |
| December 24 | "Run It!" | Chris Brown |
| December 31 | "Don't Forget About Us" | Mariah Carey |
