Hot 100 number-one hits of 2003 (United States)
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This is a list of the U.S. Billboard magazine Hot 100 number-ones of 2003.
| Issue Date | Song | Artist |
| January 4 | "Lose Yourself" | Eminem |
| January 11 | "Lose Yourself" | Eminem |
| January 18 | "Lose Yourself" | Eminem |
| January 25 | "Lose Yourself" | Eminem |
| February 1 | "Bump, Bump, Bump" | B2K featuring P. Diddy |
| February 8 | "All I Have" | Jennifer Lopez featuring LL Cool J |
| February 15 | "All I Have" | Jennifer Lopez featuring LL Cool J |
| February 22 | "All I Have" | Jennifer Lopez featuring LL Cool J |
| March 1 | "All I Have" | Jennifer Lopez featuring LL Cool J |
| March 8 | "In Da Club" | 50 Cent |
| March 15 | "In Da Club" | 50 Cent |
| March 22 | "In Da Club" | 50 Cent |
| March 29 | "In Da Club" | 50 Cent |
| April 5 | "In Da Club" | 50 Cent |
| April 12 | "In Da Club" | 50 Cent |
| April 19 | "In Da Club" | 50 Cent |
| April 26 | "In Da Club" | 50 Cent |
| May 3 | "In Da Club" | 50 Cent |
| May 10 | "Get Busy" | Sean Paul |
| May 17 | "Get Busy" | Sean Paul |
| May 24 | "Get Busy" | Sean Paul |
| May 31 | "21 Questions" | 50 Cent featuring Nate Dogg |
| June 7 | "21 Questions" | 50 Cent featuring Nate Dogg |
| June 14 | "21 Questions" | 50 Cent featuring Nate Dogg |
| June 21 | "21 Questions" | 50 Cent featuring Nate Dogg |
| June 28 | "This Is the Night" | Clay Aiken |
| July 5 | "This Is the Night" | Clay Aiken |
| July 12 | "Crazy in Love" | Beyoncé featuring Jay-Z |
| July 19 | "Crazy in Love" | Beyoncé featuring Jay-Z |
| July 26 | "Crazy in Love" | Beyoncé featuring Jay-Z |
| August 2 | "Crazy in Love" | Beyoncé featuring Jay-Z |
| August 9 | "Crazy in Love" | Beyoncé featuring Jay-Z |
| August 16 | "Crazy in Love" | Beyoncé featuring Jay-Z |
| August 23 | "Crazy in Love" | Beyoncé featuring Jay-Z |
| August 30 | "Crazy in Love" | Beyoncé featuring Jay-Z |
| September 6 | "Shake Ya Tailfeather" | Nelly, P. Diddy and Murphy Lee |
| September 13 | "Shake Ya Tailfeather" | Nelly, P. Diddy and Murphy Lee |
| September 20 | "Shake Ya Tailfeather" | Nelly, P. Diddy and Murphy Lee |
| September 27 | "Shake Ya Tailfeather" | Nelly, P. Diddy and Murphy Lee |
| October 4 | "Baby Boy" | Beyoncé featuring Sean Paul |
| October 11 | "Baby Boy" | Beyoncé featuring Sean Paul |
| October 18 | "Baby Boy" | Beyoncé featuring Sean Paul |
| October 25 | "Baby Boy" | Beyoncé featuring Sean Paul |
| November 1 | "Baby Boy" | Beyoncé featuring Sean Paul |
| November 8 | "Baby Boy" | Beyoncé featuring Sean Paul |
| November 15 | "Baby Boy" | Beyoncé featuring Sean Paul |
| November 22 | "Baby Boy" | Beyoncé featuring Sean Paul |
| November 29 | "Baby Boy" | Beyoncé featuring Sean Paul |
| December 6 | "Stand Up" | Ludacris featuring Shawnna |
| December 13 | "Hey Ya!" | OutKast |
| December 20 | "Hey Ya!" | OutKast |
| December 27 | "Hey Ya!" | OutKast |
