Hot 100 number-one hits of 1980 (United States)
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These are the Billboard magazine Hot 100 number one hits of 1980.
| Issue Date | Song | Artist |
| January 5 | "Please Don't Go" | KC and the Sunshine Band |
| January 12 | "Escape (The Piña Colada Song)" | Rupert Holmes |
| January 19 | "Rock with You" | Michael Jackson |
| January 26 | "Rock with You" | Michael Jackson |
| February 2 | "Rock with You" | Michael Jackson |
| February 9 | "Rock with You" | Michael Jackson |
| February 16 | "Do That to Me One More Time" | Captain & Tennille |
| February 23 | "Crazy Little Thing Called Love" | Queen |
| March 1 | "Crazy Little Thing Called Love" | Queen |
| March 8 | "Crazy Little Thing Called Love" | Queen |
| March 15 | "Crazy Little Thing Called Love" | Queen |
| March 22 | "Another Brick in the Wall (Part II)" | Pink Floyd |
| March 29 | "Another Brick in the Wall (Part II)" | Pink Floyd |
| April 5 | "Another Brick in the Wall (Part II)" | Pink Floyd |
| April 12 | "Another Brick in the Wall (Part II)" | Pink Floyd |
| April 19 | "Call Me" | Blondie |
| April 26 | "Call Me " | Blondie |
| May 3 | "Call Me" | Blondie |
| May 10 | "Call Me" | Blondie |
| May 17 | "Call Me" | Blondie |
| May 24 | "Call Me" | Blondie |
| May 31 | "Funkytown" | Lipps Inc |
| June 7 | "Funkytown" | Lipps Inc |
| June 14 | "Funkytown" | Lipps Inc |
| June 21 | "Funkytown" | Lipps Inc |
| June 28 | "Coming Up (live at Glasgow)" | Paul McCartney |
| July 5 | "Coming Up (live at Glasgow)" | Paul McCartney |
| July 12 | "Coming Up (live at Glasgow)" | Paul McCartney |
| July 19 | "It's Still Rock and Roll to Me" | Billy Joel |
| July 26 | "It's Still Rock and Roll to Me" | Billy Joel |
| August 2 | "Magic" | Olivia Newton-John |
| August 9 | "Magic" | Olivia Newton-John |
| August 16 | "Magic" | Olivia Newton-John |
| August 23 | "Magic" | Olivia Newton-John |
| August 30 | "Sailing" | Christopher Cross |
| September 6 | "Upside Down" | Diana Ross |
| September 13 | "Upside Down" | Diana Ross |
| September 20 | "Upside Down" | Diana Ross |
| September 27 | "Upside Down" | Diana Ross |
| October 4 | "Another One Bites the Dust" | Queen |
| October 11 | "Another One Bites the Dust" | Queen |
| October 18 | "Another One Bites the Dust" | Queen |
| October 25 | "Woman in Love" | Barbra Streisand |
| November 1 | "Woman in Love" | Barbra Streisand |
| November 8 | "Woman in Love" | Barbra Streisand |
| November 15 | "Lady" | Kenny Rogers |
| November 22 | "Lady" | Kenny Rogers |
| November 29 | "Lady" | Kenny Rogers |
| December 6 | "Lady" | Kenny Rogers |
| December 13 | "Lady" | Kenny Rogers |
| December 20 | "Lady" | Kenny Rogers |
| December 27 | "(Just Like) Starting Over" | John Lennon |
