TGFB1I1

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Transforming growth factor beta 1 induced transcript 1
Identifiers
Symbol(s) TGFB1I1; ARA55; HIC-5; HIC5; TSC-5
External IDs OMIM: 602353 MGI: 102784 HomoloGene: 7572
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7041 21804
Ensembl ENSG00000140682 ENSMUSG00000030782
Refseq NM_001042454 (mRNA)
NP_001035919 (protein)		 NM_009365 (mRNA)
NP_033391 (protein)
Location Chr 16: 31.39 - 31.4 Mb Chr 7: 128.04 - 128.05 Mb
Pubmed search [1] [2]

Transforming growth factor beta 1 induced transcript 1, also known as TGFB1I1, is a human gene.


[edit] See also

[edit] Further reading

  • Yeh S, Sampson ER, Lee DK, et al. (2001). "Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer.". J. Formos. Med. Assoc. 99 (12): 885–94. PMID 11155740. 
  • Heitzer MD, DeFranco DB (2007). "Hic-5/ARA55: a prostate stroma-specific AR coactivator.". Steroids 72 (2): 218–20. doi:10.1016/j.steroids.2006.11.010. PMID 17166536. 
  • Wilson SE, Lloyd SA (1991). "Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells.". Invest. Ophthalmol. Vis. Sci. 32 (10): 2747–56. PMID 1716619. 
  • Shibanuma M, Mashimo J, Kuroki T, Nose K (1994). "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence.". J. Biol. Chem. 269 (43): 26767–74. PMID 7929412. 
  • Shibanuma M, Mochizuki E, Maniwa R, et al. (1997). "Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts.". Mol. Cell. Biol. 17 (3): 1224–35. PMID 9032249. 
  • Matsuya M, Sasaki H, Aoto H, et al. (1998). "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.". J. Biol. Chem. 273 (2): 1003–14. PMID 9422762. 
  • Fujita H, Kamiguchi K, Cho D, et al. (1998). "Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.". J. Biol. Chem. 273 (41): 26516–21. PMID 9756887. 
  • Thomas SM, Hagel M, Turner CE (1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin.". J. Cell. Sci. 112 ( Pt 2): 181–90. PMID 9858471. 
  • Fujimoto N, Yeh S, Kang HY, et al. (1999). "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate.". J. Biol. Chem. 274 (12): 8316–21. PMID 10075738. 
  • Nishiya N, Iwabuchi Y, Shibanuma M, et al. (1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain.". J. Biol. Chem. 274 (14): 9847–53. PMID 10092676. 
  • Turner CE, Brown MC, Perrotta JA, et al. (1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling.". J. Cell Biol. 145 (4): 851–63. PMID 10330411. 
  • Liu S, Thomas SM, Woodside DG, et al. (2000). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses.". Nature 402 (6762): 676–81. doi:10.1038/45264. PMID 10604475. 
  • Yang L, Guerrero J, Hong H, et al. (2000). "Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix.". Mol. Biol. Cell 11 (6): 2007–18. PMID 10848625. 
  • Oda A, Ochs HD, Lasky LA, et al. (2001). "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk.". Blood 97 (9): 2633–9. PMID 11313252. 
  • Nishiya N, Tachibana K, Shibanuma M, et al. (2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase.". Mol. Cell. Biol. 21 (16): 5332–45. doi:10.1128/MCB.21.16.5332-5345.2001. PMID 11463817. 
  • Jia Y, Ransom RF, Shibanuma M, et al. (2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein.". J. Biol. Chem. 276 (43): 39911–8. doi:10.1074/jbc.M103510200. PMID 11546764. 
  • Ting HJ, Yeh S, Nishimura K, Chang C (2002). "Supervillin associates with androgen receptor and modulates its transcriptional activity.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 661–6. doi:10.1073/pnas.022469899. PMID 11792840. 
  • Denhez F, Wilcox-Adelman SA, Baciu PC, et al. (2002). "Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5.". J. Biol. Chem. 277 (14): 12270–4. doi:10.1074/jbc.M110291200. PMID 11805099. 
  • Wang X, Yang Y, Guo X, et al. (2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator.". J. Biol. Chem. 277 (18): 15426–31. doi:10.1074/jbc.M111218200. PMID 11856738. 

[edit] External links

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v • d • e
Transcription coregulators
Coactivators
ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1
NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)
Corepressors
Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33)
NCOR1 - NCOR2 (SMRT)
ATP-dependent remodeling factors