CRTC1

From Wikipedia, the free encyclopedia


CREB regulated transcription coactivator 1
Identifiers
Symbol(s) CRTC1; FLJ14027; KIAA0616; MECT1; TORC1; WAMTP1
External IDs OMIM: 607536 MGI: 2142523 HomoloGene: 41607
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23373 382056
Ensembl ENSG00000105662 ENSMUSG00000003575
Uniprot Q6UUV9 Q68ED7
Refseq NM_015321 (mRNA)
NP_056136 (protein)		 NM_001004062 (mRNA)
NP_001004062 (protein)
Location Chr 19: 18.66 - 18.75 Mb Chr 8: 73.31 - 73.37 Mb
Pubmed search [1] [2]

CREB regulated transcription coactivator 1, also known as CRTC1, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: CRTC1 CREB regulated transcription coactivator 1.

[edit] Further reading

  • Takemori H, Kajimura J, Okamoto M (2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain.". FEBS J. 274 (13): 3202-9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169-76. PMID 9734811. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tonon G, Modi S, Wu L, et al. (2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.". Nat. Genet. 33 (2): 208-13. doi:10.1038/ng1083. PMID 12539049. 
  • Iourgenko V, Zhang W, Mickanin C, et al. (2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12147-52. doi:10.1073/pnas.1932773100. PMID 14506290. 
  • Conkright MD, Canettieri G, Screaton R, et al. (2003). "TORCs: transducers of regulated CREB activity.". Mol. Cell 12 (2): 413-23. PMID 14536081. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Enlund F, Behboudi A, Andrén Y, et al. (2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.". Exp. Cell Res. 292 (1): 21-8. PMID 14720503. 
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824. 
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Screaton RA, Conkright MD, Katoh Y, et al. (2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.". Cell 119 (1): 61-74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Bittinger MA, McWhinnie E, Meltzer J, et al. (2005). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins.". Curr. Biol. 14 (23): 2156-61. doi:10.1016/j.cub.2004.11.002. PMID 15589160. 
  • Behboudi A, Winnes M, Gorunova L, et al. (2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.". Genes Chromosomes Cancer 43 (2): 202-5. doi:10.1002/gcc.20168. PMID 15729701. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Komiya T, Park Y, Modi S, et al. (2006). "Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation.". Oncogene 25 (45): 6128-32. doi:10.1038/sj.onc.1209627. PMID 16652146. 
  • Siu YT, Chin KT, Siu KL, et al. (2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats.". J. Virol. 80 (14): 7052-9. doi:10.1128/JVI.00103-06. PMID 16809310. 
  • Katoh Y, Takemori H, Lin XZ, et al. (2006). "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.". FEBS J. 273 (12): 2730-48. doi:10.1111/j.1742-4658.2006.05291.x. PMID 16817901. 
  • Okabe M, Miyabe S, Nagatsuka H, et al. (2007). "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma.". Clin. Cancer Res. 12 (13): 3902-7. doi:10.1158/1078-0432.CCR-05-2376. PMID 16818685. 

[edit] External links

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v • d • e
Transcription coregulators
Coactivators
ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1
NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)
Corepressors
Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33)
NCOR1 - NCOR2 (SMRT)
ATP-dependent remodeling factors