RCOR1

From Wikipedia, the free encyclopedia

REST corepressor 1

PDB rendering based on 2iw5.

Available structures: 2iw5, 2uxn, 2v1d

Identifiers

Symbol(s)

RCOR1; COREST; KIAA0071; RCOR

External IDs

OMIM: 607675 MGI: 106340 HomoloGene: 32246

Gene ontology
Molecular Function:	• DNA binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • chromatin modification

Orthologs

Human

Mouse

Refseq

NM_015156 (mRNA)
NP_055971 (protein)

NM_198023 (mRNA)
NP_932140 (protein)

Location

Chr 14: 102.13 - 102.26 Mb

Chr 12: 111.53 - 111.56 Mb

Pubmed search

[1]

[2]

REST corepressor 1, also known as RCOR1, is a human gene.^[1]

The RCOR gene encodes a functional corepressor required for regulation of neural-specific gene expression.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RCOR1 REST corepressor 1.

[edit] Further reading

Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223-9. PMID 7584044.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Andrés ME, Burger C, Peral-Rubio MJ, et al. (1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9873-8. PMID 10449787.
Grimes JA, Nielsen SJ, Battaglioli E, et al. (2000). "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.". J. Biol. Chem. 275 (13): 9461-7. PMID 10734093.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Humphrey GW, Wang Y, Russanova VR, et al. (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.". J. Biol. Chem. 276 (9): 6817-24. doi:10.1074/jbc.M007372200. PMID 11102443.
You A, Tong JK, Grozinger CM, Schreiber SL (2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex.". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454-8. doi:10.1073/pnas.98.4.1454. PMID 11171972.
Ballas N, Battaglioli E, Atouf F, et al. (2001). "Regulation of neuronal traits by a novel transcriptional complex.". Neuron 31 (3): 353-65. PMID 11516394.
Hakimi MA, Bochar DA, Chenoweth J, et al. (2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420-5. doi:10.1073/pnas.112008599. PMID 12032298.
Battaglioli E, Andrés ME, Rose DW, et al. (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex.". J. Biol. Chem. 277 (43): 41038-45. doi:10.1074/jbc.M205691200. PMID 12192000.
Lunyak VV, Burgess R, Prefontaine GG, et al. (2002). "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.". Science 298 (5599): 1747-52. doi:10.1126/science.1076469. PMID 12399542.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hakimi MA, Dong Y, Lane WS, et al. (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.". J. Biol. Chem. 278 (9): 7234-9. doi:10.1074/jbc.M208992200. PMID 12493763.
Iwase S, Januma A, Miyamoto K, et al. (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.". Biochem. Biophys. Res. Commun. 322 (2): 601-8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Gu H, Liang Y, Mandel G, Roizman B (2005). "Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells.". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7571-6. doi:10.1073/pnas.0502658102. PMID 15897453.
Lee MG, Wynder C, Cooch N, Shiekhattar R (2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.". Nature 437 (7057): 432-5. doi:10.1038/nature04021. PMID 16079794.
Shi YJ, Matson C, Lan F, et al. (2005). "Regulation of LSD1 histone demethylase activity by its associated factors.". Mol. Cell 19 (6): 857-64. doi:10.1016/j.molcel.2005.08.027. PMID 16140033.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.