SIN3A

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SIN3 homolog A, transcription regulator (yeast)
PDB rendering based on 1g1e.
Available structures: 1g1e, 1s5q, 1s5r
Identifiers
Symbol(s) SIN3A; KIAA0700; DKFZP434K2235; FLJ90319
External IDs OMIM: 607776 MGI: 107157 HomoloGene: 32124
Orthologs
Human Mouse
Entrez 25942 20466
Ensembl ENSG00000169375 ENSMUSG00000042557
Uniprot Q96ST3 Q570Z7
Refseq NM_015477 (mRNA)
NP_056292 (protein)		 NM_011378 (mRNA)
NP_035508 (protein)
Location Chr 15: 73.45 - 73.54 Mb Chr 9: 56.87 - 56.93 Mb
Pubmed search [1] [2]

SIN3 homolog A, transcription regulator (yeast), also known as SIN3A, is a human gene.

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast).

[edit] Further reading

  • Zhang Y, Dufau ML (2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes.". J. Steroid Biochem. Mol. Biol. 85 (2-5): 401-14. PMID 12943729. 
  • Halleck MS, Pownall S, Harder KW, et al. (1995). "A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3.". Genomics 26 (2): 403-6. PMID 7601471. 
  • Ayer DE, Lawrence QA, Eisenman RN (1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.". Cell 80 (5): 767-76. PMID 7889570. 
  • Hurlin PJ, Quéva C, Koskinen PJ, et al. (1996). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.". EMBO J. 14 (22): 5646-59. PMID 8521822. 
  • Hassig CA, Fleischer TC, Billin AN, et al. (1997). "Histone deacetylase activity is required for full transcriptional repression by mSin3A.". Cell 89 (3): 341-7. PMID 9150133. 
  • Laherty CD, Yang WM, Sun JM, et al. (1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression.". Cell 89 (3): 349-56. PMID 9150134. 
  • Zhang Y, Iratni R, Erdjument-Bromage H, et al. (1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.". Cell 89 (3): 357-64. PMID 9150135. 
  • Meroni G, Reymond A, Alcalay M, et al. (1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.". EMBO J. 16 (10): 2892-906. doi:10.1093/emboj/16.10.2892. PMID 9184233. 
  • Lin RJ, Nagy L, Inoue S, et al. (1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia.". Nature 391 (6669): 811-4. doi:10.1038/35895. PMID 9486654. 
  • David G, Alland L, Hong SH, et al. (1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein.". Oncogene 16 (19): 2549-56. doi:10.1038/sj.onc.1202043. PMID 9627120. 
  • Wong CW, Privalsky ML (1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6.". J. Biol. Chem. 273 (42): 27695-702. PMID 9765306. 
  • Zhang Y, LeRoy G, Seelig HP, et al. (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.". Cell 95 (2): 279-89. PMID 9790534. 
  • Tong JK, Hassig CA, Schnitzler GR, et al. (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.". Nature 395 (6705): 917-21. doi:10.1038/27699. PMID 9804427. 
  • Koipally J, Renold A, Kim J, Georgopoulos K (1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.". EMBO J. 18 (11): 3090-100. doi:10.1093/emboj/18.11.3090. PMID 10357820. 
  • Boutell JM, Thomas P, Neal JW, et al. (2000). "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.". Hum. Mol. Genet. 8 (9): 1647-55. PMID 10441327. 
  • Zhang Y, Ng HH, Erdjument-Bromage H, et al. (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.". Genes Dev. 13 (15): 1924-35. PMID 10444591. 
  • Kao HY, Downes M, Ordentlich P, Evans RM (2000). "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression.". Genes Dev. 14 (1): 55-66. PMID 10640276. 
  • Huang S, Brandt SJ (2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor.". Mol. Cell. Biol. 20 (6): 2248-59. PMID 10688671. 
  • Koipally J, Georgopoulos K (2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.". J. Biol. Chem. 275 (26): 19594-602. doi:10.1074/jbc.M000254200. PMID 10766745. 
  • Yu F, Thiesen J, Strätling WH (2000). "Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2.". Nucleic Acids Res. 28 (10): 2201-6. PMID 10773092. 

[edit] External links

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v • d • e
Transcription coregulators
Coactivators
ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1
NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)
Corepressors
Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33)
NCOR1 - NCOR2 (SMRT)
ATP-dependent remodeling factors