CRTC2

From Wikipedia, the free encyclopedia


CREB regulated transcription coactivator 2
Identifiers
Symbol(s) CRTC2; RP11-422P24.6; TORC2
External IDs OMIM: 608972 MGI1921593 HomoloGene18765
Orthologs
Human Mouse
Entrez 200186 74343
Ensembl ENSG00000160741 ENSMUSG00000027936
Refseq NM_181715 (mRNA)
NP_859066 (protein)
NM_028881 (mRNA)
NP_083157 (protein)
Location Chr 1: 152.19 - 152.2 Mb Chr 3: 90.34 - 90.35 Mb
Pubmed search [1] [2]

CREB regulated transcription coactivator 2, also known as CRTC2, is a human gene.[1]


[edit] References

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Iourgenko V, Zhang W, Mickanin C, et al. (2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12147-52. doi:10.1073/pnas.1932773100. PMID 14506290. 
  • Conkright MD, Canettieri G, Screaton R, et al. (2003). "TORCs: transducers of regulated CREB activity.". Mol. Cell 12 (2): 413-23. PMID 14536081. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Screaton RA, Conkright MD, Katoh Y, et al. (2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.". Cell 119 (1): 61-74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. 
  • Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.". J. Cell. Sci. 118 (Pt 23): 5661-73. doi:10.1242/jcs.02670. PMID 16306228. 
  • Siu YT, Chin KT, Siu KL, et al. (2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats.". J. Virol. 80 (14): 7052-9. doi:10.1128/JVI.00103-06. PMID 16809310. 
  • Wu Z, Huang X, Feng Y, et al. (2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.". Proc. Natl. Acad. Sci. U.S.A. 103 (39): 14379-84. doi:10.1073/pnas.0606714103. PMID 16980408. 
  • Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.". Genes Dev. 20 (20): 2820-32. doi:10.1101/gad.1461206. PMID 17043309. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Ravnskjaer K, Kester H, Liu Y, et al. (2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.". EMBO J. 26 (12): 2880-9. doi:10.1038/sj.emboj.7601715. PMID 17476304. 
  • Kuraishy AI, French SW, Sherman M, et al. (2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation.". Proc. Natl. Acad. Sci. U.S.A. 104 (24): 10175-80. doi:10.1073/pnas.0704170104. PMID 17548807. 

[edit] External links