IL1A
From Wikipedia, the free encyclopedia
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Interleukin 1, alpha
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| PDB rendering based on 2ila. | ||||||||||||||
| Available structures: 2ila | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | IL1A; IL-1A; IL1; IL1-ALPHA; IL1F1 | |||||||||||||
| External IDs | OMIM: 147760 MGI: 96542 HomoloGene: 480 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3552 | 16175 | ||||||||||||
| Ensembl | ENSG00000115008 | ENSMUSG00000027399 | ||||||||||||
| Uniprot | P01583 | Q3U0Y6 | ||||||||||||
| Refseq | NM_000575 (mRNA) NP_000566 (protein) |
NM_010554 (mRNA) NP_034684 (protein) |
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| Location | Chr 2: 113.25 - 113.26 Mb | Chr 2: 128.99 - 129 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Interleukin 1, alpha, also known as IL1A, is a human gene.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Verweij CL, Bayley JP, Bakker A, Kaijzel EL (2002). "Allele specific regulation of cytokine genes: monoallelic expression of the IL-1A gene.". Adv. Exp. Med. Biol. 495: 129–39. PMID 11774556.
- Griffin WS, Mrak RE (2002). "Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease.". J. Leukoc. Biol. 72 (2): 233–8. PMID 12149413.
- Arend WP (2003). "The balance between IL-1 and IL-1Ra in disease.". Cytokine Growth Factor Rev. 13 (4-5): 323–40. PMID 12220547.
- Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines.". Mini reviews in medicinal chemistry 5 (12): 1093–101. PMID 16375755.
- Schmidt DR, Kao WJ (2007). "The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function.". Biomaterials 28 (3): 371–82. doi:. PMID 16978691.
- Huynh-Ba G, Lang NP, Tonetti MS, Salvi GE (2007). "The association of the composite IL-1 genotype with periodontitis progression and/or treatment outcomes: a systematic review.". J. Clin. Periodontol. 34 (4): 305–17. doi:. PMID 17378887.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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