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[edit] Overview
Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30).[1] IL-27 is produced by antigen-presenting cells.[2] IL-27 plays an important function in regulating the activity of B and T lymphocytes.[3] The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL-27R and gp130. The gene symbol IL27 refers to the IL-30 subunit of IL-27.[4]
[edit] References
- ^ F. Larousserie et al., Analysis of Interleukin-27 (EBI3/p28) Expression in Epstein-Barr Virus- and Human T-Cell Leukemia Virus Type 1-Associated Lymphomas Heterogeneous Expression of EBI3 Subunit by Tumoral Cells, American Journal of Pathology, 2005, Volume 166, pages 1217-1228.
- ^ IL-27 regulates IL-12 responsiveness of naive CD4 [Proc Natl Acad Sci U S A. 2003] - PubMed Result
- ^ F. Larousserie et al., Differential Effects of IL-27 on Human B Cell Subsets. Journal of Immunology, 2006, Volume 176, pages 5890-5897.
- ^ http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157
