Interleukin 28

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Interleukin 28A
Identifiers
Symbol	IL28A
Alt. Symbols	, IFNL2
Entrez	282616
HUGO	18364
OMIM	607401
RefSeq	NM_172138
UniProt	Q8IZJ0
Other data
Locus	Chr. 19 q13.13

Interleukin 28B
Identifiers
Symbol	IL28B
Alt. Symbols	, IFNL3
Entrez	282617
HUGO	18365
OMIM	607402
RefSeq	NM_172139
UniProt	Q8IZI9
Other data
Locus	Chr. 19 q13.13

Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses.^[1] IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29.

IL-28 genes are located near IL-29 on chromosome 19 in humans.

[edit] References

1. ^ D. Kempuraj et al., Interleukin-28 and 29 (IL-28 and IL-29): new cytokines with anti-viral activities. International Journal of Immunopathology and Pharmacology, 2004, Volume 17, pages 103-106.

v • d • e Cytokines: interleukins IL-1 superfamily IL-1 (IL-1Ra) - IL-18 - IL-33 IL-6 like/gp130 utilizing IL-6 - IL-11 - IL-27 - IL-30 - IL-31 (+non IL Oncostatin M, Leukemia inhibitory factor, Ciliary neurotrophic factor, Cardiotrophin 1) IL-10 family IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26 Interferon type III IL-28 - IL-29 Common γ-chain family IL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21 IL-12 family IL-12 - IL-23 - IL-27 - IL-35 Other IL-5 - IL-8 - IL-14 - IL-16 - IL-17/IL-25 (A) - IL-32

v • d • e Cytokines: interferons Interferon type I alpha (Pegylated interferon alfa-2a - Pegylated interferon alfa-2b), beta (Interferon beta-1a - Interferon beta-1b) Interferon type II Interferon-gamma Interferon type III Interleukin 28 - Interleukin 29