Interleukin 19

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Crystal structure of human IL-19
Interleukin 19
Identifiers
Symbol	IL19
Alt. Symbols	, MDA1, ZMDA1, IL-10C
Entrez	29949
HUGO	5990
OMIM	605687
PDB	1N1F
RefSeq	NM_153758
UniProt	Q9UHD0
Other data
Locus	Chr. 1 q32.2

Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide.^[1]

[edit] References

1. ^ Chang, C. et al., Crystal Structure of Interleukin-19 Defines a New Subfamily of Helical Cytokines. Journal of Biological Chemistry, 2003, Volume 278, pages 3308-3313.

v • d • e Cytokines: interleukins IL-1 superfamily IL-1 (IL-1Ra) - IL-18 - IL-33 IL-6 like/gp130 utilizing IL-6 - IL-11 - IL-27 - IL-30 - IL-31 (+non IL Oncostatin M, Leukemia inhibitory factor, Ciliary neurotrophic factor, Cardiotrophin 1) IL-10 family IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26 Interferon type III IL-28 - IL-29 Common γ-chain family IL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21 IL-12 family IL-12 - IL-23 - IL-27 - IL-35 Other IL-5 - IL-8 - IL-14 - IL-16 - IL-17/IL-25 (A) - IL-32