Terbutaline
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Terbutaline
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| Systematic (IUPAC) name | |
| 5-(1-hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol | |
| Identifiers | |
| CAS number | |
| ATC code | R03 R03CC03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C12H19NO3 |
| Mol. mass | 225.284 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | GI tract (oral), liver; CYP450: unknown |
| Half life | urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B |
| Legal status | |
| Routes | SQ, Oral, Inhaled |
Terbutaline (trade names Brethine, Bricanyl, or Brethaire) is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour. The inhaled form of terbutaline starts working within 15 minutes and can last up to 6 hours.
Terbutaline as a treatment for premature labour is an off-label use not approved by the FDA. It is a pregnancy category 'B' medication and is routinely prescribed to stop contractions. Terbutaline is currently on the World Anti-Doping Agency's list of prohibited drugs, except, when administered by inhalation, a Therapeutic Use Exemption (TUE) has been obtained in advance.
[edit] Side effects
- Maternal - tachycardia, nervousness, tremors, headache and possible pulmonary edema.
- Fetal - tachycardia and hypoglycemia.
Terbutaline is preferred over Ritodrine because it has minimal effects on blood pressure.
[edit] References
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